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효소발효 백하수오의 고지혈증 흰쥐에 대한 지질대사 개선 효능 연구
Lipid Improvement Effect of Fermented Cynanchi wilfordii Radix in Hyperlipidemia Rats

대한본초학회지 2015년 30권 6호 p.83 ~ p.91

풍수김(Feng Xiu-Jin) - 대전대학교 한의과대학 본초학연구실
노성수(Roh Seong-Soo) - 대구한의대학교 한의과대학 본초약리학교실
오당섭(Oh Dang-Seop) - 농업회사법인 (주)오디에스식품
서영배(Seo Young-Bae) - 대전대학교 한의과대학 본초학연구실

Abstract

Objectives : The present study was conducted to examine whether Cynanchi wilfordii radix (CWR) with or without fermentation has an ameliorative effect on hyperlipidemia in rats.

Methods : We analyzed the contents of Conduritol F on Cynanchi wilfordii radix. The experimental animals were divided into six groups; normal diet fed group (N), high cholesterol fed control group (Con), Lovastatin 20 mg/kg (L), CWR-W 300 mg/kg (CWR-W), and CWR-F 300 mg/kg on hyperlipidemia model induced by feeding 1.25% cholesterol. Rats were administrated orally every day for 8 weeks. And lipid profile of serum and weight change were observed.

Results : The vehicle displayed a markedly increased body weight and significantly increased liver and epididymal fat weight, however, the administration of CWR improved the body, liver, and epididymal fat weights. All drug treatment reduced significantly the serum level of total cholesterol and LDL-cholesterol elevated by intake of high cholesterol diet. TG displayed a reducing tendency all drug treatment, however, CWR-W decreased significantly. Atherogenic index and cardiac risk factor increased high cholesterol diet fed control group, while the administration of CWR-W and CWR-F decreased significantly. The major index of liver injury such as AST and ALT improved in all drug treatment.

Conclusions : These results suggest that CWR extended the effect of lipid enhanced. Therefore CWR with or without fermentation may be useful for therapeutic treatment of clinical conditions associated with hyperlipidemia. Finally, these require more investigations about the action mechanism of CWR in the future.

키워드

Cynanchi wilfordii radix, High cholesterol diet, Hyperlipidemia, Fermentation

KMID : 0861020150300060083

원문 및 링크아웃 정보

KISTI

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

백수오를 투여함으로 인해 체중 감소효과를 모두에서 볼 수 있었고, 백수오원물투여군이 혈중 지질농도중 TC, TG 및 LDL-C 모두를 조절하여 유의적인 감소를 보이는 것으로 나타났다. 또한, 백수오원물과 백수오 발효추출물이 동맥경화지수와 심혈관위험지수를 유의적으로 감소시키는 것으로 나타났다.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

http://dx.doi.org/10.6116/kjh.2015.30.6.83.

KCD코드

ICD 03

건강보험코드

효소발효 백하수오의 고지혈증 흰쥐에 대한 지질대사 개선 효능 연구 Lipid Improvement Effect of Fermented Cynanchi wilfordii Radix in Hyperlipidemia Rats

Abstract

키워드

효소발효 백하수오의 고지혈증 흰쥐에 대한 지질대사 개선 효능 연구
Lipid Improvement Effect of Fermented Cynanchi wilfordii Radix in Hyperlipidemia Rats