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A Case of Seizure and Metabolic Acidosis Due to Renal Adjustment Dosage of Isoniazid in an Elderly Woman

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½Å¿µ½Å(Shin Young-Shin) - ´ëµ¿º´¿ø ³»°ú
½ÉÀºÈñ(Sim Eun-Hee) - ´ëµ¿º´¿ø ³»°ú
¿©Ã¢¿ì(Yeo Chang-Woo) - ´ëµ¿º´¿ø ³»°ú
°­ÁøµÎ(Kang Jin-Du) - ´ëµ¿º´¿ø ³»°ú
±èÁö¿¬(Kim Ji-Yeon) - ´ëµ¿º´¿ø ³»°ú
¹Ú¼±ÀÚ(Park Seun-Ja) - °í½Å´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç

Abstract

Isoniazid is one of the most commonly used antituberculosis drug. Acute into xication is characterized by repetitious convulsions, high anion gap metabolic a cidosis and coma. The basis of theraphy consists of parental pyridoxine admi nistration in a dose equivalent to that of isoniazid ingested. Here we present a case of seizure and metabolic acidosis due to only renal adjustment dosage of Isoniazid in an elderly woman.

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Isoniazid, Metabolic acidosis, Pyridoxine, Seizure
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