Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks oRelief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Groupf Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group
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(Lopez-Alvarenga Juan Carlos) - Hospital General de Mexico OD Direccion de Investigacion
(Orr William C) - University of Oklahoma Health Sciences Center Lynn Institute for Healthcare Research
(Vargas-Romero Jose Antonio) - Takeda Mexico S.A. de C.V Medical Research Department
(Remes-Troche Jose Maria) - UV-Universidad Veracruzana Instituto de Investigaciones Medico Biologicas
(Morales-Arambula Miguel) - Hospital General de Occidente Departamento de Gastroenterologia
(Soto-Perez Julio Cesar) - Hospital de Alta Especialidad PEMEX Sur Departamento de Endoscopia
(Mateos-Perez Gualberto) - Hospital Angeles del Pedregal Departamento de Cirugia General y Gastroenterologia
(Sobrino-Cossio Sergio) - Mexico Instituto Nacional de Cancerologia Department of Endoscopy
(Teramoto-Matsubara Oscar) - Hospital ABC Departamento de Endoscopia
(Lopez-Colombo Aurelio) - Mexico Instituto Mexicano del Seguro Social (IMSS) Coordinacion de Investigacion en Salud
(Orozco-Gamiz Antonio) - Laboratorio de Fisiologia Digestiva Clinical Research Gastrolab S.A. de C.V.,
(Saez-Rios Adolfo) - Takeda Mexico S.A. de C.V Medical Research Department
(Arellano-Plancarte Araceli) - Takeda Mexico S.A. de C.V Medical Research Department
(Chiu-Ugalde Jazmin) - Takeda Mexico S.A. de C.V Medical Research Department
(Tholen Anne) - Takeda Pharmaceuticals International GmbH Global Medical Affairs
(Horbach Silke) - Takeda Pharmaceuticals International GmbH Global Medical Affairs
(Lundberg Lars) - Takeda Pharmaceuticals International GmbH Global Medical Affairs
(Fass Ronnie) - Case Western Reserve University MetroHealth Medical Center Division of Gastroenterology and Hepatology
Abstract
Background/Aims: To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and ex-tra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms.
Methods: Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the pa-tient-completed ReQuest in PracticeTM questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms.
Results: Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P £¼ 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks im-proved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduc-tion on ReQuest in PracticeTM dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated.
Conclusions: Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms in-cluding sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present.
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Gastroesophageal, Night-time symptoms, Pantoprazole, Proton pump inhibitors
KMID :
0812020140200010064
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