ÃÊÀ½ÆÄ·Î Áø´ÜµÈ ºñ¾ËÄÚ¿Ã Áö¹æ°£ ȯÀÚ¿¡¼ Cytokeratin-18°ú ´ë»ç ÁöÇ¥¿ÍÀÇ »ó°ü°ü°è
Clinical Correlation between Serum Cytokeratin-18 and Metabolic Parameters in Patients with Sonographic Non-alcoholic Fatty Liver Disease
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°ûµ¿½Å(Kwak Dong-Shin) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Àü´ë¿ø(Jun Dae-Won) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Á¶¿µ±Õ(Cho Young-Kyun) - ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ °ºÏ»ï¼ºº´¿ø ³»°úÇб³½Ç
À̽¹Î(Lee Seung-Min) - ¼º½Å¿©ÀÚ´ëÇб³ ½ÄÇ°¿µ¾çÇаú
À̼¼È¯(Lee Sae-Hwan) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇРõ¾Èº´¿ø ³»°úÇб³½Ç
Á¤Àμ·(Jung In-Sub) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
À̼º¿ø(Lee Sung-Won) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
ÀÌÁ¤ÈÆ(Lee Jung-Hoon) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
ÀÌÀº¿µ(Lee Eun-Young) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
³ë¹Î(Rho Min) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
ÀÌ°·Ï(Lee Kang-Lok) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
°íÁرÇ(Ko Jun-Kwon) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¹Ú¼øÀÀ(Park Soon-Eung) - ÇѾç´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Abstract
Background/Aims: The serum cytokeratin-18 (CK-18) has been suggested to be a surrogate marker of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the correlation between CK-18 and metabolic parameter in NAFLD patients. Correlation between CK-18 and macronutrient composition was also assessed.
Methods: A total of 212 subjects were recruited. Blood chemistry including fasting glucose, cholesterol level, AST, ALT, and CK-18 were compared. Data on calorie intake and carbohydrate consumption were acquired by five-day-diet diary using 24 hour recall method.
Results: Plasma CK-18 were markedly increased in patient with NAFLD compared with control group (420.4¡¾282.3 vs. 313.6¡¾179,p£¼0.001). Plasma CK-18 were positively correlated with systolic blood pressure (r=0.130), ALT (r=0.503) and negatively correlated with HDL cholesterol (r=?0.246). NAFLD patients with metabolic syndrome had higher CK-18 level than those without metabolic syndrome (484.0 vs. 372.1 U/L, p=0.021). When NAFLD patients were subdivided into two groups with CK-18 cut-off value of 400 U/L, patients with CK-18 level over 400 U/L showed higher body mass index (28.0¡¾4.5 vs. 25.5¡¾4.3), subcutaneous abdominal fat (283.5¡¾172.2 vs. 195.7¡¾147.8), AST (52.7¡¾26.3 vs. 40.7¡¾23.5) and ALT (102.0¡¾52.6 vs. 61.2¡¾32.2). Calorie intake (r=0.301) and carbohydrate intake (r=0.305) also showed positive correlation with CK-18.
Conclusions: Plasma CK-18 showed positive correlation with metabolic parameters as well as calorie and carbohydrate intake when its cut-off value of greater than 400 U/L was used.
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Non-alcoholic fatty liver disease, Keratin-18, Metabolic syndrome, Carbohydrates
KMID :
0614620140640040206
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