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Clinical Features of Non-alcoholic Fatty Liver Disease in Cryptogenic Hepatocellular Carcinoma
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Àӹοµ(Rim Min-Young) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
±Ç¿À»ó(Kwon Oh-Sang) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
ÇϹμö(Ha Min-Su) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
±èÁÖ½Â(Kim Ju-Seung) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
°í±¤ÀÏ(Ko Kwang-Il) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
±èµ¿±Ô(Kim Dong-Kyu) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
ÀåÇʱÔ(Jang Pil-Kyu) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
ÇÑÁ¤À±(Han Jung-Yoon) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
¹ÚÆòÈ(Park Pyung-Hwa) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
Á¤¿µ°É(Jung Young-Kul) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
ÃÖ´öÁÖ(Choi Duck-Joo) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
±è¿¬¼ö(Kim Yun-Soo) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
±èÁÖÇö(Kim Ju-Hyeon) - °¡Ãµ´ëÇб³ ±æº´¿ø ³»°úÇб³½Ç
Abstract
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether patients with cryptogenic HCC share clinical features similar to that of NAFLD.
Methods: Cryptogenic HCC was defined as HCC that occurs in patients with the following conditions: HBsAg(?), anti-HCV(?), and alcohol ingestion of less than 20 g/day. All patients diagnosed with cryptogenic HCC from 2005 to 2012 (cryptogenic HCC group), and all patients diagnosed with HBV associated HCC between 2008 and 2012 (HBV-HCC group) were enrolled in the present study. Clinical features, BMI, lipid profiles, presence of diabetes mellitus, hypertension, and metabolic syndrome were compared between the two groups.
Results: Cryptogenic HCC group was composed of 35 patients (19 males and 16 females) with a mean age of 70¡¾11 years. HBV-HCC group was composed of 406 patients (318 males and 88 females) with a mean age of 56¡¾7 years. Patients in the cryptogenic HCC group were older (p=0.001) and female dominant (p=0.042) than those in the HBV-HCC group. There were no differences in the laboratory test results including lipid profiles and Child-Turcotte-Pugh class between the two groups. Patients in the cryptogenic HCC group had higher prevalence of diabetes (37% vs. 17%, p=0.015), hypertension (49% vs.27%, p=0.051), metabolic syndrome (37% vs. 16%, p=0.001), and higher BMI (25.3 kg/m2 vs. 24.1 kg/m2, p=0.042) than those in the HBV- HCC group. The tumor stage was more advanced (stage III and IV) at diagnosis in the cryptogenic HCC group than in the HBV-HCC group (60% vs. 37%, p=0.007).
Conclusions: Cryptogenic HCC has clinical features similar to that of NAFLD and is diagnosed at a more advanced tumor stage.
Å°¿öµå
Cryptogenic, Hepatocellular carcinoma, Metabolic syndrome, Nonalcoholic fatty liver disease
KMID :
0614620140630050292
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