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생후 90일 이하의 영아에서 호흡기 바이러스 검출과 관련된 위험인자
Risk Factors Associated with Respiratory Virus Detection in Infants Younger than 90 Days of Age

소아감염 2014년 21권 1호 p.22 ~ p.28

임연주(Eem Yeun-Joo) - 가톨릭대학교 의과대학 소아과학교실
배이영(Bae E-Young) - 가톨릭대학교 의과대학 소아과학교실
이정현(Lee Jung-Hyun) - 가톨릭대학교 의과대학 소아과학교실
정창모(Jeong Chang-Mo) - 가톨릭대학교 의과대학 소아과학교실

Abstract

Purpose: This study aimed at determining the detection rate of respiratory viruses and at investigating the risk factors associated with respiratory virus detection in young infants.

Methods: From September 2011 to August 2012, nasopharyngeal swabs were obtained from 227 infants aged ≤90 days with suspected infectious diseases, including sepsis. We performed a retrospective analysis of their clinical characteristics. The prevalence of respiratory viruses in their nasopharyngeal swabs was assayed by real-time polymerase chain reaction (real-time PCR).

Results: In total, 157 (69.2%) infants had more than one of the following respiratory viruses: respiratory syncytial virus (n= 75), rhinovirus (n=42), influenza virus (n=18), parainfluenza virus (n=15), human metapneumovirus (n=9), coronavirus (n=9), adenovirus (n=4), and bocavirus (n=3). During the same period, bacterial infections were confirmed in 24 infants (10.6%). The detection of respiratory viruses was significantly associated with the presence of cough, a family history of respiratory illness, and a seasonal preference (fall/winter). Using logistic regression analysis, these 3 variables were also identified as significant risk factors. During fall and winter, detection of respiratory viruses was significantly higher in infants who did not have a bacterial infection.

Conclusion: Respiratory virus is an important pathogen in young infants admitted to a hospital, who are suspected with infectious diseases. Detection of respiratory viruses in young infants was associated with seasonality (fall/winter), presence of respiratory symptoms and a family history of respiratory illness.

키워드

Infants, Nasopharynx, Virus disease, Respiratory tract infections, Real-time polymerase chain reaction

KMID : 0605820140210010022

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주제코드

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연구대상(Population)

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질병특성(Condition Category)

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유효성결과(Recomendation)

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DOI

KCD코드

ICD 03

건강보험코드

생후 90일 이하의 영아에서 호흡기 바이러스 검출과 관련된 위험인자 Risk Factors Associated with Respiratory Virus Detection in Infants Younger than 90 Days of Age

Abstract

키워드

생후 90일 이하의 영아에서 호흡기 바이러스 검출과 관련된 위험인자
Risk Factors Associated with Respiratory Virus Detection in Infants Younger than 90 Days of Age