Patients with Acute Respiratory Distress Syndrome Caused by Scrub Typhus: Clinical Experiences of Eight Patients
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±è¼±¿µ(Kim Sun-Young) - Inje University College of Medicine Haeundae Paik Hospital Department of Internal Medicine
ÀåÇ×Á¦(Jang Hang-Jae) - Inje University College of Medicine Haeundae Paik Hospital Department of Internal Medicine
±èÇö±¹(Kim Hyun-Kuk) - Inje University College of Medicine Haeundae Paik Hospital Department of Internal Medicine
½Å°æÈ(Shin Kyung-Hwa) - Daedong Hospital Department of Internal Medicine
±è¹ÌÇö(Kim Mi-Hyun) - Pusan National University School of Medicine Pusan National University Hospital Department of Internal Medicine
À̱¤ÇÏ(Lee Kwang-Ha) - Pusan National University School of Medicine Pusan National University Hospital Department of Internal Medicine
±è±â¿í(Kim Ki-Uk) - Pusan National University School of Medicine Pusan National University Hospital Department of Internal Medicine
¹ÚÇý°æ(Park Hye-Kyung) - Pusan National University School of Medicine Pusan National University Hospital Department of Internal Medicine
À̹αâ(Lee Min-Ki) - Pusan National University School of Medicine Pusan National University Hospital Department of Internal Medicine
Abstract
Background: The aim of this study is to describe the clinical course and outcome of patients who were diagnosed with acute respiratory distress syndrome (ARDS) caused by scrub typhus and who received ventilator care in the intensive care units (ICU) of two university hospitals.
Methods: We performed a retrospective analysis of all adult ventilated patients who were diagnosed with ARDS caused by scrub typhus.
Results: Eleven (1.7%) of 632 scrub typhus patients were diagnosed with ARDS (median age 72; seven were male). Eight patients had underlying diseases, the most common of which was hypertension (four patients). Eight patients (72.7%) were admitted in November. The most common chief complaints of the patients were fever and rash (63.6%). All patients had skin eschar and rash; seven were treated for shock. On the day of diagnosis with ARDS, the median Acute Physiology and Chronic Health Evaluation score was 20 (range 11-28) and Sequential Organ Failure Assessment score was 7 (range 4-14). All patients had PaO2/FiO2 < 200 mmHg, high serum aspartate aminotransferase level (> 40 IU/L), and hypoalbuminemia (< 3.3 g/dl). Nine patients were treated with doxycycline on the day of admission. Their median lengths of stay in the ICU and hospital were 10 (range 4-65) and 14 (4-136) days, respectively. The mortality rate during treatment in the hospital was 36.4%.
Conclusions: In our study, the risk of ARDS among patients diagnosed with scrub typhus was at least 1.7%, with a hospital mortality rate of 36.4%.
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acute respiratory distress syndrome, intensive care unit, scrub typhus
KMID :
0604020140290030189
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