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Clinical Evaluation of Human Papillomavirus DNA Genotyping Assay to Diagnose Women Cervical Cancer

대한의생명과학회지 2012년 18권 2호 p.123 ~ p.130

김성현(Kim Sung-Hyun) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
이동섭(Lee Dong-Sup) - Yonsei University Wonju College of Health Sciences Department of Biomedical Laboratory Science
김예은(Kim Ye-un) - Yonsei University Wonju College of Health Sciences Department of Biomedical Laboratory Science
김기혁(Kim Gee-Hyuk) - Yonsei University Wonju College of Health Sciences Department of Biomedical Laboratory Science
박상정(Park Sang-Jung) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
최연임(Choi Yeon-Im) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
김태우(Kim Tae-Ue) - Yonsei University College of Health Science Department of Biomedical Laboratory Science
박광하(Park Kwang-Hwa) - Yonsei University Wonju College of Medicine Department of Pathology
이혜영(Lee Hye-Young) - Yonsei University College of Health Science Department of Biomedical Laboratory Science

Abstract

In this study, we evaluated the human papillomavirus (HPV) genotyping test called MolecuTech REBA HPV-ID® (YD Diagnostics, Seoul, Korea) for 704 women who also had cervical cytological evaluations by Thin Prep. The infection rate of high-risk HPV genotypes was 56.6% in patients with normal cytology, 59.8% in those with benign, low-grade squamous intraepithelial lesions, 51.4% in those with atypical squamous cells of uncertain significance, 92.3% in those with high-grade squamous intraepithelial lesions, and 94.1% in those with squamous cell carcinoma or adenocarcinoma. HPV 16 was the most common genotype detected in any lesion, followed by HPV 53, 58, 33, 52, 45, 31, and 35, in order. The HPV DNA test with PCR-REBA is a very highly sensitive, but less specific, method. The infection rates and HPV genotype distribution of non-Korean people versus people from South Korea showed regional differences.

키워드

Human papillomavirus (HPV), Women cervical cancer, Clinical evaluation, PCR-REBA

KMID : 0603820120180020123

원문 및 링크아웃 정보

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구결과 자궁경부의 세포병리학적 으로 SCC, HSIL에서의 HPV 고위험군의 감염률이 약 92% 이상으로 검출되었고, HPV 저위험군의 감염률은 약 3% 미만으로 나타났으며, 또한 조직병리학적 고등급 병 변인 Invasive cancer, CIN-2, CIN-3, CIS에서의 HPV 고위 험군의 감염률이 약 85% 이상으로 검출되었고, HPV 저 위험군의 감염률은 약 4% 미만으로 나타났기 때문에 고 등급 병변에서의 HPV DNA 유전자형 검사법의 분석적 민감도나 임상적 특이도가 모두 뛰어남을 알 수 있었다.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드