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Usefulness of Electroencephalography after Partial Sleep Deprivation for the Diagnosis of Epilepsy in Children
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Á¤¼¼È(Jung Se-Hwa) - ¾ÆÁÖ´ëÇб³ Àǰú´ëÇÐ ¼Ò¾ÆÃ»¼Ò³â°úÇб³½Ç
±è¼ºÈ¯(Kim Sung-Hwan) - ¾ÆÁÖ´ëÇб³ Àǰú´ëÇÐ ¼Ò¾ÆÃ»¼Ò³â°úÇб³½Ç
Abstract
¸ñÀû: ¼Ò¾ÆÃ»¼Ò³â ȯÀÚ ±º¿¡¼ ¼ö¸é ¹ÚÅ» ÈÄ ³úÆÄ°Ë»ç¸¦ ½ÃÇàÇϸé EDs °ËÃâ·üÀ» ³ôÀÏ ¼ö ÀÖ´ÂÁö¿¡ ´ëÇØ ³í¶õÀÇ ¿©Áö°¡ ÀÖÀ¸¸ç, ÀÏ»ó Áø·á¿¡¼ ¿¬·ÉÀÌ ¾î¸° ȯÀÚ¿¡°Ô ¸ðµÎ SDEEG¸¦ Àû¿ëÇϱâ´Â ¾î·Á¿î ½ÇÁ¤ÀÌ´Ù. º» ¿¬±¸´Â EDs °ËÃâ·üÀÌ REEG¿¡¼ º¸´Ù SDEEG¿¡¼ ´õ ³ôÀºÁö ºÐ¼®ÇÏ¿© ÀÓ»ó¿¡¼ ³úÀüÁõ Áø´ÜÀ» À§ÇØ ¼Ò¾ÆÃ»¼Ò³â ȯÀÚ¿¡°Ô SDEEG¸¦ Àû¿ëÇÏ´Â µ¥¿¡ ±Ù°Å°¡ ÃæºÐÇÑÁö ¾Ë¾Æº¸±â À§ÇØ ½ÃÇàµÇ¾ú´Ù.
¹æ¹ý: 219¸íÀÇ È¯ÀÚ¿¡¼ ½ÃÇàµÈ 219°ÇÀÇ ³úÆÄ°Ë»ç¸¦ ¿¬±¸ ´ë»óÀ¸·Î Æ÷ÇÔÇÏ¿© Àǹ« ±â·ÏÀ» ÈÄÇâÀûÀ¸·Î ºÐ¼®ÇÏ¿´À¸¸ç, 150°ÇÀÇ REEG, 69°ÇÀÇ SDEEG°¡ ½ÃÇàµÇ¾ú´Ù. °¢ ³úÆÄ°Ë»ç ±º¿¡¼ EDs °ËÃâ·ü°ú ¼ö¸é ±â·Ï ¿©ºÎ¿¡ µû¸¥ EDs °ËÃâ·üÀ» ºñ±³ ºÐ¼®ÇÏ¿´´Ù. ¶ÇÇÑ EDs °ËÃâ·üÀÌ SDEEG ±º¿¡¼ ³ô´Ù¸é ÀÌ´Â ¼ö¸é ¶§¹®ÀÎÁö ¾Æ´Ï¸é ¼ö¸é ¹ÚÅ» ÀÚü·Î ÀÎÇØ ¿µÇâÀ» ¹ÞÀº °ÍÀÎÁö¸¦ ¾Ë±â À§ÇØ ¼ö¸éÀÌ ±â·Ï µÈ ³úÆÄ°Ë»ç±º°ú ¼ö¸éÀÌ ±â·Ï ¾ÈµÈ ³úÆÄ°Ë»ç ±º¿¡¼ EDs °ËÃâ·üÀ» ºÐ¼®ÇÏ¿´°í, ¼ö¸éÀÌ ±â·ÏµÈ ³úÆÄ°Ë»ç ±º¿¡¼ REEG ±º°ú SDEEG ±ºÀ¸·Î ³ª´² °¢°¢ÀÇ EDs °ËÃâ·üÀ» ºñ±³ ºÐ¼®ÇÏ¿´´Ù.
°á°ú: REEG¸¦ ½ÃÇàÇÑ ±º º¸´Ù SDEEG¸¦ ½ÃÇàÇÑ ±º¿¡¼ EDs °ËÃâ·üÀÌ Åë°èÀûÀ¸·Î À¯ÀÇÇÏ°Ô ³ô¾Ò´Ù(43.3% vs 59.4%, P=0.03)(Fig. 1, 2). REEG¸¦ ½ÃÇàÇÑ ³úÆÄ°Ë»ç ±º¿¡¼´Â ¼ö¸éÀÌ ±â·ÏµÇ°Å³ª ±â·ÏµÇÁö ¾ÊÀº °¢ ±º¿¡¼ EDsÀÇ °ËÃâ·ü¿¡ Åë°èÀûÀ¸·Î À¯ÀÇÇÑ Â÷À̰¡ ¾ø¾úÀ¸³ª (43.8% vs 38.5%, P=0.777), SDEEG¸¦ ½ÃÇàÇÑ ±º¿¡¼ ¼ö¸éÀÌ ±â·ÏµÇ¸é ¼ö¸éÀÌ ±â·ÏµÇÁö ¾ÊÀº °æ¿ì º¸´Ù Åë°èÀûÀ¸·Î À¯ÀÇÇÏ°Ô EDs °ËÃâ·üÀÌ ³ô¾Ò´Ù(61.9% vs 33.3%, P=0.022)(Fig. 1). Àüü ³úÆÄ°Ë»ç¿¡¼ ¼ö¸éÀÌ ±â·ÏµÈ ³úÆÄ°Ë»ç ±ºÀÌ ¼ö¸éÀÌ ±â·ÏµÇÁö ¾ÊÀº ³úÆÄ°Ë»ç ±º º¸´Ù EDsÀÇ °ËÃâ·üÀÌ ³ô¾ÒÀ¸³ª Åë°èÀûÀ¸·Î ÀÇ¹Ì ÀÖ´Â Â÷ÀÌ´Â ¾ø¾ú°í(49.5% vs 36.8%, P=0.342)(Fig. 3), ¼ö¸éÀÌ ±â·ÏµÈ ³úÆÄ°Ë»ç ±º¿¡¼ REEG ±º°ú SDEEG ±ºÀÇ EDs °ËÃâ·üÀ» ºñ±³ÇÒ ¶§ SDEEG ±º¿¡¼ EDs °ËÃâ·üÀÌ Åë°èÀûÀ¸·Î ÀÇ¹Ì ÀÖ°Ô ³ô¾Ò´Ù(43.8% vs 61.9%, P=0.022)(Fig.4).
°á·Ð: SDEEG¸¦ ½ÃÇàÇϸé REEG¸¦ ½ÃÇàÇÒ ¶§ º¸´Ù EDsÀÇ °ËÃâ·üÀÌ ³ô°í, SDEEG¿¡¼ EDsÀÇ °ËÃâ·üÀÌ ³ôÀº °ÍÀº ¼ö¸é¹ÚÅ»·Î ÀÎÇØ ¼ö¸éÀÌ Àß À¯µµµÇ¾ú±â ¶§¹®ÀÌ ¾Æ´Ï¶ó ¼ö¸é ¹ÚÅ» ÀÚü·Î ÀÎÇÑ È¿°ú¶ó »ý°¢ÇÒ ¼ö ÀÖ´Ù. µû¶ó¼ °æ·Ã¹ßÀÛÀ¸·Î ³»¿øÇÑ ¼Ò¾ÆÃ»¼Ò³â ȯÀÚÀÇ ÀÓ»óÁø·á¿¡¼ SDEEG¸¦ Åë»óÀûÀ¸·Î Àû¿ëÇÑ´Ù¸é °£Áú¹ßÀÛ°ú ³úÀüÁõ Áø´Ü¿¡ µµ¿òÀ» ÁÙ ¼ö ÀÖÀ» °ÍÀÌ´Ù.
Purpose: The benefit of electroencephalography after sleep deprivation (SDEEG) in the diagnosis of epilepsy is controversial, and it is difficult to apply SDEEG to all pediatric patients in the clinical setting. This study is to figure out the usefulness of SDEEG for the detection of epileptiform discharges (EDs).
Methods: Medical records were reviewed retrospectively. Routine electroencephalography (REEG) was performed in 150 patients, and SDEEG was taken in 69 patients among the study population(n=219). The detection rates of EDs were compared between two groups, and also compared according to the presence of sleep in each group.
Results: The detection rate of EDs was higher in SDEEG group than in REEG group [n=69 (59.4%) vs n=150 (43.3%), P=0.03). Whereas there was no significant differences of the detection rate of EDs between REEG with and without sleep recording groups (43.8% vs 38.5%, P=0.777), there was significantly higher detection rate of EDs in SDEEG with sleep than SDEEG without sleep recording groups [n=63 (61.9%) vs n=6 (33.3%), P=0.022]. The detection rate of EDs was not significantly different between each group with and without sleep recording in overall EEGs (49.5% vs 36.8%, P=0.342). However, in overall EEGs with sleep recording, the detection rate of EDs was statistically significantly higher in SDEEG group than REEG group [n=63 (61.9%) vs n=137 (43.8%), P=0.022].
Conclusion: SDEEG revealed higher detection rate of EDs than REEG. It is not because of the effect of sleep recording, but of sleep deprivation itself. SDEEG is useful tool to apply for the diagnosis of epilepsy in daily clinical practice in children.
Ű¿öµå
Electroencephalography, Sleep Deprivation, Epilepsy
KMID :
0391520140220020082
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