Progression Rate of Aortic Valve Stenosis in Korean Patients

Journal of Cardiovascular Ultrasound 2010년 18권 4호 p.127 ~ p.133

류동렬(Ryu Dong-Ryeol) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
박성지(Park Sung-Ji) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
한혜진(Han Hye-Jin) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
이현종(Lee Hyun-Jong) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
장성아(Chang Sung-A) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
최진오(Choi Jin-Oh) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
이상철(Lee Sang-Chul) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
박승우(Park Seung-Woo) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology
(Oh Jae-K) - Sungkyunkwan University School of Medicine Samsung Medical Center Division of Cardiology

Abstract

Background: Although there were studies about ethnic differences in aortic valve thickness and calcification that they may play a role in aortic valvular stenosis (AVS) progression, few studies about the progression rate of AVS in Asian population have been reported. The purpose of this study was to evaluate the progression rate of AVS in Korean patients.

Methods: We retrospectively analyzed 325 patients (181 men, age: 67 ± 13 years) with AVS who had 2 or more
echocardiograms at least 6 months apart from 2003 to 2008. The patients with other significant valvular diseases or history of cardiac surgery were excluded. The progression rate of AVS was expressed in terms of increase in maximum aortic jet velocity per year (meter/second/year).

Results: Baseline AVS was mild in 207 (64%), moderate in 81 (25%), and severe in 37 (11%). There were no significant differences among the three groups in terms of age, gender, hypertension, smoking, and hypercholesterolemia. The mean progression rate was 0.12 ± 0.23 m/s/yr and more rapid in severe AVS (0.28 ± 0.36 m/s/yr) when compared to moderate (0.14 ± 0.26 m/s/yr) and mild AVS (0.09 ± 0.18 m/s/yr) (p < 0.001). The progression rate in bicuspid AVS was significantly higher than other AVS (0.23 ± 0.35 vs. 0.11 ± 0.20 m/s/yr, p = 0.002). By multivariate analysis, initial maximum aortic jet velocity (Beta = 0.175, p = 0.003), bicuspid aortic valve (Beta = 0.127, p = 0.029), and E velocity (Beta = -0.134, p = 0.018) were significantly associated with AVS progression.

Conclusion: The progression rate of AVS in Korean patients is slower than that reported in Western population. Therefore, ethnic difference should be considered for the follow-up of the patients with AVS.

키워드

Aortic valvular stenosis, Natural history, Disease progression
원문 및 링크아웃 정보
등재저널 정보
학술진흥재단(KCI) KoreaMed 대한의학회 회원 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
The progression rate of AVS in Korean patients is slower than that reported in Western population; AVS progresses more rapidly in severe AVS than in moderate or mild AVS; The progression rate in bicuspid AVS was significantly higher than other AVS (0.23 ± 0.35 vs. 0.11 ± 0.20 m/s/yr, p = 0.002).
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드