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Pulmonary Cryptococcosis in a Patient with Ankylosing Spondylitis treated with Etanercept
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ÀÓäȣ(Lim Chae-Ho) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
ÀÌ»óÇå(Lee Sang-Heon) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ·ù¸¶Æ¼½º³»°úÇб³½Ç
±èÈ£¿¬(Kim Ho-Youn) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ·ù¸¶Æ¼½º³»°úÇб³½Ç
±è¿Ï¼·(Kim Wan-Seop) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø º´¸®Çб³½Ç
°¼ºÈñ(Kang Seong-Hui) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
±Ç¼¼¿õ(Kwon Se-Woong) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
±èÁö¿Ï(Kim Ji-Wan) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
¹Ú¼ö¿¬(Park Soo-Youn) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
¾È»óÈñ(An Sang-Hee) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
À¯Çü¹Î(Yu Hyung-Min) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ³»°úÇб³½Ç
±èÇظ²(Kim Hae-Rim) - °Ç±¹´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ·ù¸¶Æ¼½º³»°úÇб³½Ç
Abstract
Ankylosing spondylitis (AS) is a chronic inflammatory dis-order, commonly characterized by inflammation of axial skeleton and development of enthesopathies. Tumor ne-crosis factor inhibitors (TNFi) shows good therapeutic re-sponses in AS patients without good response to non-ster-oidal anti-inflammatory drugs. Although TNFi are rela-tively safe for AS patients, serious opportunistic infections, including tuberculosis and fungal infection, could develop. Here, according to our knowledge, we report a first Korean case of pulmonary cryptococcosis in a patient with AS treated with etanercept. A 64 year-old man with AS visited due to a newly appeared pulmonary nodule on a routine chest radiography. He had been administered eta-nercept for 5 months. Histologic findings of the lung nod-ule showed characteristic features of cryptococcosis. Etanercept was discontinued and oral fluconazole was ad-ministrated, as there was no evidence of central nervous system involvement. After 7 months of treatment, chest CT showed an improvement of the pulmonary lesion.
Å°¿öµå
Ankylosing spondylitis, Pulmonary crypto-coccosis, Etanercept, Tumor necrosis factor inhibitor
KMID :
0388220140210040214
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