KCTBASE

불응성 용혈성 빈혈을 지닌 소아 전신홍반루푸스에서의 Rituximab 치료 1례
Delayed and Long-term Remission of Refractory Hemolytic Anemia in a Child with Systemic Lupus Erythematosus Treated with Rituximab

대한류마티스학회지 2014년 21권 4호 p.196 ~ p.200

박주환(Park Ju-Hwan) - 울산대학교 의과대학 울산대학교병원 내과학교실
임재욱(Im Jae-Uk) - 울산대학교 의과대학 울산대학교병원 내과학교실
전홍길(Jun Hong-Gil) - 울산대학교 의과대학 울산대학교병원 내과학교실
박혜민(Park Hye-Min) - 울산대학교 의과대학 울산대학교병원 내과학교실
최승원(Choi Seung-Won) - 울산대학교 의과대학 울산대학교병원 내과학교실
박상규(Park Sang-Kyu) - 울산대학교 의과대학 울산대학교병원 소아과학교실
오지선(Oh Ji-Seon) - 울산대학교 의과대학 울산대학교병원 내과학교실

Abstract

Autoimmune hemolytic anemia (AIHA) is a relatively com-mon cause of anemia in children and adults with systemic lupus erythematosus (SLE). Although AIHA responds to steroids, in case of refractory or steroid-dependent AIHA, immunosuppressants and intravenous immunoglobulin have been used as second line agents. Rituximab, an anti-CD20 monoclonal antibody, is emerging in the treatment of SLE refractory to conventional therapy. Herein, we report a case of delayed and sustained remission of refractory hemolytic anemia in a child with SLE, post rituximab treatment. A 12-year-old female child with dizziness was referred to our department and was diagnosed with SLE combined with he-molytic anemia and renal tubular acidosis. Since frequent relapse of hemolytic anemia had occurred during the ste-roid tapering course, even though she had been treated with additional immunosuppressants (azathioprine, mycopheno-late mofetil), the patient received 2 doses of rituximab 500 mg at 2 weeks interval at 18 months post diagnosis. After 15 months of rituximab administration, her anemia and re-nal tubular acidosis were fully recovered, enough to stop all medications. She remained well without recurrence for up to 3 years and 4 months after rituximab treatment.

키워드

Systemic lupus erythematosus, Hemolytic ane-mia, Rituximab, Steroid

KMID : 0388220140210040196

원문 및 링크아웃 정보

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

불응성 용혈성 빈혈을 지닌 소아 전신홍반루푸스에서의 Rituximab 치료 1례 Delayed and Long-term Remission of Refractory Hemolytic Anemia in a Child with Systemic Lupus Erythematosus Treated with Rituximab

Abstract

키워드

불응성 용혈성 빈혈을 지닌 소아 전신홍반루푸스에서의 Rituximab 치료 1례
Delayed and Long-term Remission of Refractory Hemolytic Anemia in a Child with Systemic Lupus Erythematosus Treated with Rituximab