Çѱ¹ ¼Ò¾Æ±â ·ù¸¶Æ¼½º°üÀý¿° ȯÀÚ¿¡¼ Human Leukocyte Antigen-DRB1 ´ë¸³À¯ÀüÀÚ¿ÍÀÇ ¿¬°ü¼º
Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis
´ëÇÑ·ù¸¶Æ¼½ºÇÐȸÁö 2014³â 21±Ç 4È£ p.182 ~ p.186
ÀÌÂùÀç(Lee Chan-Jae) - ÇѸ²´ëÇб³ ÀÇ°ú´ëÇÐ ¼º½Éº´¿ø ¼Ò¾Æû¼Ò³â°úÇб³½Ç
¼ÕÅ¿µ(Sohn Tae-Young) - ÇѸ²´ëÇб³ ÀÇ°ú´ëÇÐ ¼º½Éº´¿ø ¼Ò¾Æû¼Ò³â°úÇб³½Ç
ÀÌ´ëÇü(Lee Dae-Hyoung) - ÇѸ²´ëÇб³ ÀÇ°ú´ëÇÐ ¼º½Éº´¿ø ¼Ò¾Æû¼Ò³â°úÇб³½Ç
ÀÌÇý¶õ(Lee Hae-Ran) - ÇѸ²´ëÇб³ ÀÇ°ú´ëÇÐ ¼º½Éº´¿ø ¼Ò¾Æû¼Ò³â°úÇб³½Ç
±è¹Ì¿µ(Kim Mi-Young) - ÇѸ²´ëÇб³ ¼º½Éº´¿ø Áø´Ü°Ë»çÀÇÇаú±³½Ç
±è±¤³²(Kim Kwang-Nam) - ÇѸ²´ëÇб³ ÀÇ°ú´ëÇÐ ¼º½Éº´¿ø ¼Ò¾Æû¼Ò³â°úÇб³½Ç
Abstract
Objective: The aim of this study is to investigate the associ-ation of different subgroups of juvenile rheumatoid arthri-tis (JRA) with human leukocyte antigen (HLA) class II DR alleles.
Methods: One hundred and nineteen Korean juvenile rheu-matoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls.
Results: HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with poly-articular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA pa-tients than the controls.
Conclusion: The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be ex-tended to include larger numbers of patients.
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Juvenile rheumatoid arthritis, Human leuko-cyte antigen, HLA-DRB1
KMID :
0388220140210040182
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