Propylthiouracil¿¡ ÀÇÇÑ Anti-neutrophil Cytoplasm Antibody¾ç¼º ±«Àú¼º ³óÇÇÁõ 1¿¹
A Case of Propylthiouracl induced Anti-neutrophil Cytoplasm Antibody Positive Pyoderma Gangrenosum

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ÀÌÁö¿¬(Lee Ji-Yeon) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
ÀÌÁö¹Î(Lee Ji-Min) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
ÀÌÅÂÇÑ(Lee Tae-Hwan) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
Á¤ÇýÁø(Jeong Hye-Jin) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
ÃÖ°í(Choi Go) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
äÁø³ç(Chae Jin-Nyeong) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
±èÁö¹Î(Kim Ji-Min) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
±è»óÇö(Kim Sang-Hyun) - °è¸í´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç

Abstract

Pyoderma gangrenosum (PG) is a rare disease that causes chronic skin ulcers, and it has recently been known to be related to changes in the immune system such as dysfunc-tion of neutrophils. Over 50% of patients with PG have an underlying systemic disease, and rarely are there various medicines causing the disease, including iodide, bromide, and isotretinoin. A 49-year-old man had recurrent skin ul-cers in his lower extremities. He had a history of taking propylthiouracil (PTU) for 10 years as a treatment for Graves¡¯ disease. Here, we describe a case of PTU-induced ANCA positive PG in a patient with hyperthyroidism, who has been improved after the cessation of PTU.

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Pyoderma gangrenosum, Propylthiouracil, ANCA
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