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The Systemic Rheumatologic Disease and Neuromyelitis Optica
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ÇöÇý¼÷(Hyun Hye-Sook) - ±¹¸³¾Ï¼¾ÅÍ ½Å°æ°ú
±è¼öÇö(Kim Su-Hyun) - ±¹¸³¾Ï¼¾ÅÍ ½Å°æ°ú
±èÈ£Áø(Kim Ho-Jin) - ±¹¸³¾Ï¼¾ÅÍ ½Å°æ°ú
Abstract
Neuromyelitis optica (NMO), an autoimmune in-flammatory disease of the central nervous system (CNS), is related with autoantibodies for aquaporin-4, which is the most abundant water channel in CNS. The clinical syndromes of NMO, such as longitudinally extensive trans-verse myelitis and optic neuritis, can occur in the context of systemic rheumatologic diseases, such as systemic lupus erythematosus and Sjogren syndrome. It is debatable as to whether NMO is a feature of genetic tendency toward humoral autoimmunity or a CNS complication of systemic rheumatologic diseases. Current evidence suggests that NMO coexists with systemic rheumatologic diseases rather than a complication from them. Early immunosuppressive therapies should be considered in these patients since just one or two attacks can cause severe neurological disability.
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Systemic rheumatologic disease, Neuromyelitis optica, Comorbidity, Complication
KMID :
0388220140210010004
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