Æó¾Ï ȯÀÚ¿¡¼ Docetaxel Ç×¾Ï ¿ä¹ý Ä¡·á ÈÄ ¹ß»ýÇÑ ÇǺΰæÈÁõ 1¿¹
A Case of Skin Sclerosis Associated with Docetaxel Chemotherapy for Non-Small Cell Lung Cancer
´ëÇÑ·ù¸¶Æ¼½ºÇÐȸÁö 2013³â 20±Ç 3È£ p.198 ~ p.201
³²ÀçÇü(Nam Jae-Hyung) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç È£Èí±â-¾Ë·¹¸£±â³»°ú
¹®Á¾ÁÖ(Moon Jong-Joo) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç È£Èí±â-¾Ë·¹¸£±â³»°ú
ÀÌÁØÇõ(Lee June-Hyuk) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç È£Èí±â-¾Ë·¹¸£±â³»°ú
¹Ú¼º¿ì(Park Sung-Woo) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç È£Èí±â-¾Ë·¹¸£±â³»°ú
Àå¾È¼ö(Jang An-Soo) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç È£Èí±â-¾Ë·¹¸£±â³»°ú
±èµµÁø(Kim Do-Jin) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç È£Èí±â-¾Ë·¹¸£±â³»°ú
ÀüÂùÈ«(Jeon Chan-Hong) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç ·ù¸¶Æ¼½º³»°ú
°íÀº¼®(Koh Eun-Seok) - ¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
Abstract
A 64-year-old woman was diagnosed with non-small cell lung cancer. Her disease was stage 4 (T2N2M1) with squamous cell carcinoma. She had been treated with docetaxel and carboplatin. After a completion of 11 cycle of chemotherapy, edema appeared on both feet and had spread rapidly up to the pretibial area without response to diuretics. Sclerotic changes and pigmentation followed but both knees and other parts of the body were spared. There was no evidence of vascular occlusions. On serologic tests, antinuclear, anti-centromere, and anti-topoisomerase I antibodies were all negative. A skin biopsy revealed diffuse infiltration of lymphocytes and discretely thickened collagen bundles in the superficial dermis. After discontinuing docetaxel chemotherapy, she was treated with prednisolone and D-penicillamine and sclerotic changes on the lower legs were improved.
Å°¿öµå
Docetaxel, Scleroderma, Lung cancer, Adverse effect
KMID :
0388220130200030198
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)
After discontinuing docetaxel chemotherapy, she was treated with prednisolone and D-penicillamine and sclerotic changes on the lower legs were improved.