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The Effects of Marathon Running on Retinol Binding Protein 4 and C-reactive Protein Levels in Healthy Middle-aged Korean Men

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äÁö¼÷(Chae Ji-Suk) - ¿¬¼¼´ëÇб³ ±³À°°úÇдëÇÐ ½ºÆ÷Ã÷·¹ÀúÇаú
±è¼º¹Î(Kim Sung-Min) - ¿¬¼¼´ëÇб³ ±³À°°úÇдëÇÐ ½ºÆ÷Ã÷·¹ÀúÇаú
ÀÌÁ¤¾Æ(Lee Jung-A) - ¿¬¼¼´ëÇб³ ±³À°°úÇдëÇÐ ½ºÆ÷Ã÷·¹ÀúÇаú
Àü¿ë°ü(Jeon Justin Y.) - ¿¬¼¼´ëÇб³ ±³À°°úÇдëÇÐ ½ºÆ÷Ã÷·¹ÀúÇаú

Abstract

¹è°æ: º» ¿¬±¸´Â ±Þ¼ºÀ¯»ê¼Ò¿îµ¿À¸·Î ±¸¼ºµÈ 1ȸ¼º ¸¶¶óÅæ(42.195 km) ´Þ¸®±â°¡ °Ç°­ÇÑ Á߳Ⳳ¼ºÀÇ Retinol Binding Protein 4 (RBP4) ¹× C-reactive protein (CRP)¿Í »ý¸®ÇÐÀû Ç÷¾×¼ººÐ¿¡ ¾î¶°ÇÑ ¿µÇâÀ» ¹ÌÄ¡´Â°¡¸¦ ±Ô¸íÇÏ´Â µ¥ ¸ñÀûÀÌ ÀÖ´Ù.

¹æ¹ý: º» ¿¬±¸ÀÇ ´ë»óÀÚ´Â ÀÎÅÍ³Ý ¸¶¶óÅæ µ¿È£È¸ »çÀÌÆ®¿¡¼­ ¿¬±¸°øÁö¸¦ ÅëÇØ ¸ðÁýÇÏ¿´°í, ´ç´¢º´·ÂÀÌ ¾ø´Â 40-50´ë Á߳Ⳳ¼º ÃÑ 14¸íÀÌ ¿¬±¸¿¡ Âü¿©ÇÏ¿´´Ù. ¿îµ¿±º(N= 8)Àº °ú°Å ¸¶¶óÅæÀ» ¿ÏÁÖÇÑ °æÇèÀÌ ÀÖ°í, °ú°Å¿¡ ¸¶¶óÅæ¿¡ Âü¿©ÇÑ °æÇèÀÌ ¾ø´Â °Ç°­ÇÑ Á߳Ⳳ¼ºÀ¸·Î ´ëÁ¶±º(N= 6)À» ±¸¼ºÇÏ¿´´Ù. ¿îµ¿±º¸¸ ¸¶¶óÅæÀ» ¿ÏÁÖÇÏ¿´°í, ´ëÁ¶±ºÀº ¸¶¶óÅæ¿¡ Âü¿©ÇÏÁö ¾Ê°í ÈÞ½ÄÀ» ÃëÇÏ¿´´Ù.

°á°ú: ¸¶¶óÅæ´Þ¸®±â(Æò±Õ¿ÏÁֽð£: 256.75¡¾11.52 min)´Â RBP4 (pre: 86.63¡¾28.87 vs post: 92.22¡¾42.20 ¥ìg/mL)¿Í CRP (pre: 0.04¡¾0.04 vs post: 0.04¡¾0.04 mg/dL) Ç÷Áß ³óµµ¿¡ ¿µÇâÀ» ¹ÌÄ¡Áö ¾Ê¾Ò´Ù. ±×·¯³ª ¸¶¶óÅæ´Þ¸®±â´Â ¹éÇ÷±¸ ¼öÄ¡(White blood cell, pre: 5.80¡¾1.64 th/mm3, post: 13.62¡¾3.62 th/mm3, P< 0.001)¿Í ÃÑ ÄÝ·¹½ºÅ×·Ñ(Total cholesterol, pre: 177.38¡¾41.79 mg/dL, post: 182.25¡¾42.84 mg/dL, P< 0.05) ¼öÄ¡¸¦ À¯ÀÇÇÏ°Ô Áõ°¡½ÃÄ×´Ù.

°á·Ð: 1ȸ¼º ±Þ¼ºÀ¯»ê¼Ò¿îµ¿Àº °Ç°­ÇÑ Á߳Ⳳ¼ºÀÇ ±Þ¼º¿°Áõ¹ÝÀÀ ÀÎÀÚÀÎ WBC¸¦ »ó½Â½ÃÄ×Áö¸¸, RBP4¿Í CRP¿¡´Â ¿µÇâÀ» ¹ÌÄ¡Áö ¾Ê´Â °ÍÀ¸·Î ³ªÅ¸³µ´Ù. Ãß°¡ÀûÀ¸·Î ¸¶¶óÅæ ´Þ¸®±â¿Í °ü·ÃµÈ WBC, RBP4, CRP¸¦ Æ÷ÇÔÇÏ´Â »ý¸®ÇÐÀû ÁöÇ¥¿¡ °üÇÑ ¿¬±¸°¡ Áö¼ÓµÇ¾î¾ß ÇÑ´Ù.
Background: The purpose of this study was to investigate the effects of marathon running (42.195 km) on retinol binding protein4 (RBP4) and C-reactive protein (CRP) in healthy middle aged Korean men.

Methods: Fourteen men aged from 40 to 50 participated in the current study. Eight participants completed marathon running while six participants in the control group took a rest. Blood samples were collected 90 minutes before running the marathon and right after it. Blood samples from the control group were drawn approximately at the same time.
Results: Marathon running (average marathon finishing time: 256.75¡¾11.52 min) did not influence plasma levels of RBP4 (pre: 86.63¡¾28.87 vs. post: 92.22¡¾42.20 ¥ìg/mL) or CRP (pre: 0.04¡¾0.04 vs. post: 0.04¡¾0.04 mg/dL). After running the marathon, white blood cells increased by 235% (pre: 5.80¡¾1.64 th/mm3 vs. post: 13.62¡¾3.62 th/mm3). Total cholesterol level also increased significantly after marathon running (P<0.05).

Conclusion: Marathon running did not affect RBP4 or CRP levels, but it increased WBC level significantly. Further studies are needed to elucidate the exact physiological indicators associated with marathon running, as in WBC, RBP4, and CRP.

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RBP4, ±Þ¼ºÀ¯»ê¼Ò¿îµ¿, ¸¶¶óÅæ, Çѱ¹Á߳Ⳳ¼º
RBP4, Acute aerobic exercise, Marathon, Middle-aged Korean men
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