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Comparison of Changes in Body Weight and Serum Lipid Profile after Roux-en-Y Gastric Bypass between Non-obese Patients and Obese Patients

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¹ÚÁ¤È¯(Park Jung-Hwan) - ÇѾç´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
È«»ó¸ð(Hong Sang-Mo) - ÇѾç´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
ÀÌâ¹ü(Lee Chang-Beom) - ÇѾç´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
¾ÈÀ¯Çå(Ahn You-Hern) - ÇѾç´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç
±èµ¿¼±(Kim Dong-Sun) - ÇѾç´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç

Abstract

¹è°æ: º» ¿¬±¸ÀÇ ¸ñÀûÀº üÁú·®Áö¼ö°¡ ³ôÁö ¾ÊÀº ȯÀÚ¿¡¼­ÀÇ ºñ¸¸¼ö¼úÀÇ È¿°ú¸¦ ¾Ë¾Æº¸´Â °ÍÀ¸·Î ºñ¸¸¼ö¼ú°ú °°Àº º¹°­°æ ·ç¿ÍÀÌ À§¿ìȸ¼úÀ» ½ÃÇà¹ÞÀº Á¶±â À§¾Ï ȯÀÚµéÀ» ´ë»óÀ¸·Î ¼ö¼ú Àü°ú ºñ±³ÇÏ¿©¼ö¼ú ÈÄÀÇ Ã¼Áß°ú Ç÷Áß ÁöÁú ³óµµ º¯È­¸¦ ºÐ¼®ÇÏ¿´´Ù.

¹æ¹ý: Á¶±â À§¾ÏÀ¸·Î º¹°­°æ ·ç¿ÍÀÌ À§¿ìȸ¼úÀ» ½ÃÇà¹ÞÀº 116¸íÀÇ È¯ÀÚ¸¦ ´ë»óÀ¸·Î ÇÏ¿´À¸¸ç, ¼ö¼ú Àü üÁßÀ» ÀÌ¿ëÇÑ ½ÅüÁú·®Áö¼ö 25 kg/m2À» ±âÁØÀ¸·Î ºñºñ¸¸±º(N=76)°ú ºñ¸¸±º(N= 40)À¸·Î ±¸ºÐÇÏ¿´´Ù. ¼ö¼ú ÀüÈÄ 3°³¿ù, 6°³¿ù, 9°³¿ù, 12°³¿ùÀÇ Ã¼Áß ¹× Ç÷Áß ÁöÁú ³óµµ¸¦ Á¶»çÇÏ¿´´Ù.

°á°ú: ºñºñ¸¸±º°ú ºñ¸¸±º ¸ðµÎ ¼ö¼ú Àü°ú ºñ±³ÇÏ¿© ¼ö¼ú ÈÄ¿¡ üÁß°ú Áß¼ºÁö¹æÀÇ À¯ÀÇÇÑ(P< 0.05) °¨¼Ò°¡ ÀÖ¾ú´Ù. °í¹ÐµµÁöÁú´Ü¹é ÄÝ·¹½ºÅ×·ÑÀÇ °æ¿ì ºñ¸¸±º¿¡¼­ ¼ö¼ú 3°³¿ù Èĸ¦ Á¦¿ÜÇϰí À¯ÀÇÇÑ(P< 0.05) Áõ°¡°¡ ÀÖ¾ú´Ù. ÃÑ ÄÝ·¹½ºÅ׷Ѱú Àú¹ÐµµÁöÁú´Ü¹é ÄÝ·¹½ºÅ׷ѵµ °¨¼ÒÇÏ¿´Áö¸¸ ÀϺο¡¼­¸¸ À¯ÀÇÇÑ(P< 0.05) Â÷À̸¦ º¸¿´´Ù. ºñºñ¸¸±º°ú ºñ¸¸±º¿¡¼­ÀÇ ¼ö¼ú ÈÄ Ã¼Áß°ú Ç÷Áß ÁöÁú ³óµµÀÇ º¯È­À²À» ºñ±³Çϸé üÁß°ú Áß¼ºÁö¹æÀÇ °æ¿ì ºñ¸¸±º¿¡¼­ ´õ Å« °¨¼ÒÀ²À» º¸¿´À¸³ª, ÀϺο¡¸¸ À¯ÀÇÇÑ(P< 0.05) Â÷À̸¦ º¸¿´´Ù. °í¹ÐµµÁöÁú´Ü¹éÀÇ °æ¿ì ºñºñ¸¸±º¿¡¼­ ´õ Å« Áõ°¡À²À» º¸¿´À¸³ª, µÎ ±º °£ÀÇ À¯ÀÇÇÑ Â÷ÀÌ´Â ¾ø¾ú´Ù. ÃÑ ÄÝ·¹½ºÅ׷Ѱú Àú¹ÐµµÁöÁú´Ü¹é ÄÝ·¹½ºÅ×·ÑÀÇ °æ¿ì °¨¼ÒÀ²¿¡¼­ µÎ ±º °£ÀÇ À¯ÀÇÇÑ Â÷ÀÌ´Â ¾ø¾ú´Ù.

°á·Ð: ºñºñ¸¸±º°ú ºñ¸¸±º ¸ðµÎ¿¡¼­ ·ç¿ÍÀÌ À§¿ìȸ¼ú 12°³¿ù ÈÄ¿¡ üÁß, Áß¼ºÁö¹æ, °í¹ÐµµÁöÁú´Ü¹é ÄÝ·¹½ºÅ×·Ñ, Àú¹ÐµµÁöÁú´Ü¹é ÄÝ·¹½ºÅ×·Ñ¿¡¼­ À¯ÀÇÇÑ È£ÀüÀ» º¸¿´´Ù. ÇÏÁö¸¸ ºñ¸¸±º°ú ºñ±³ÇÏ¿© ºñºñ¸¸±º¿¡¼­ÀÇ Ã¼Áß °¨¼ÒÀ²Àº À¯ÀÇÇÏ°Ô Àû¾úÀ¸¸ç, À¯ÀÇÇÏÁö´Â ¾ÊÁö¸¸ Áß¼ºÁö¹æµµ ÀûÀº °¨¼ÒÀ²À» º¸¿´´Ù. °í¹ÐµµÁöÁú´Ü¹éµµ ÄÝ·¹½ºÅ×·ÑÀº À¯ÀÇÇÏÁö ¾ÊÁö¸¸ ºñºñ¸¸±º¿¡¼­ ´õ Å« Áõ°¡À²À» º¸¿´´Ù.
Background: This study was aimed to investigate the effects of bariatric surgery in non-obese patients through the comparison of the changes in body weight (BW) and serum lipid profile between non-obese and obese patients after Roux-en-Y gastric bypass.

Methods: In this study, 116 patients who received laparoscopic Roux-en-Y gastric bypass due to early gastric cancer were included. Patients were divided into two groups, non-obese group (N=76), defined as body mass index <25 kg/m2, and obese group (N=40), body mass index ¡Ã25 kg/m2. BW and serum lipid profile before surgery and at 3, 6, 9, and 12 months after surgery were examined.

Results In all groups, BW and triglyceride (TG) showed significant (P<0.05) decrease after surgery, while high-density lipoprotein cholesterol (HDL-C) showed a significant increase during the first 3 months after surgery, in obese group. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) decreased. However, the effect was significant for only a limited time period after surgery. Mean percentages of BW loss and TG decrease were greater in the obese group after surgery, however, the change was significant for only a limited time period after surgery. Mean percentage of HDL-C increase in non-obese group was greater but was not statistically significant. There were no differences in mean percentages of total cholesterol and LDL-C decrease between the two groups.

Conclusion: At 12 months after surgery, all groups showed significant improvement in BW and serum lipid profile. However, mean percentages in BW loss, TG decrease, and HDL-C increase between the two groups were different.

Ű¿öµå

ºñ¸¸¼ö¼ú, ·ç¿ÍÀÌ À§¿ìȸ¼ú, ÁöÁú
Bariatric surgery, Roux-en-Y gastric bypass, Lipids
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ÇмúÁøÈïÀç´Ü(KCI) KoreaMed ´ëÇÑÀÇÇÐȸ ȸ¿ø 
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Áúº´Æ¯¼º(Condition Category)
¿¬±¸È¯°æ(Setting)
¿¬±¸¼³°è(Study Design)
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ÁßÀç¹æ¹ý(Intervention Type)
ÁßÀç¸íĪ(Intervention Name)
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À¯È¿¼º°á°ú(Recomendation)
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ÃâÆÇ³âµµ(Year)
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DOI
KCDÄÚµå
ICD 03
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