ÀڱðæºÎ¾Ï¿¡¼ Interleukin-6 Àü»çÁ¶ÀýºÎÀ§ ´ÙÇü¼ºÀÇ ÀÓ»óÀû ÀÇÀÇ
The Clinical Significance of Interleukin-6 Promoter Polymorphism in Cervical Cancer
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±è¿¬Á¤(Kim Y.-J.) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
¹®Çý¼º(Moon Hye-Sung) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Á¤Çý¿ø(Chung Hye-Won) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±è¼ºÃ¶(Kim Seung-Cheol) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÇü·¡(Kim Hyung-Rae) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »ýÈÇб³½Ç
Abstract
¸ñÀû: IL-6 Àü»çÁ¶ÀýºÎÀ§ÀÇ ´ÜÀÏ¿°±â¼¿´ÙÇü¼ºÀÌ ÀڱðæºÎ¾ÏÀÇ ¹ß»ý°ú ¿¹ÈÄ¿Í ¿¬°ü¼ºÀ» °®´ÂÁö¸¦ º¸°íÀÚÇÏ¿´´Ù.
¿¬±¸¹æ¹ý: °Ç°ÇÑ ¿©¼º 130¸í°ú ÀڱðæºÎ¾ÏȯÀÚ 109¸íÀ¸·ÎºÎÅÍ Ã¤ÃëÇÑ Ç÷¾×¿¡¼ DNA¸¦ ÃßÃâÇÏ¿© allele ƯÀÌ ÁßÇÕÈ¿¼Ò¿¬¼â¹ÝÀÀÀ» ÅëÇØ IL-6 Àü»çÁ¶ÀýºÎÀ§ÀÇ ´ÜÀÏ¿°±â¼¿´ÙÇü¼ºÀ» ºÐ¼®ÇÏ¿´´Ù.
°á°ú: IL-6 Àü»çÁ¶ÀýºÎÀ§ Áß 572 ºÎÀ§¿¡¼ÀÇ À¯ÀüÀÚÇü ºÐÆ÷´Â ÀڱðæºÎ¾ÏȯÀÚ±º¿¡¼ GGÇüÀÌ 55¸í(50.5%), GCÇüÀÌ 45¸í(41.3%), CCÇüÀÌ 9¸í(8.2%)À¸·Î ´ëÁ¶±º°ú Åë°èÇÐÀûÀÎ Â÷ÀÌ°¡ ¾ø¾ú´Ù.
°á·Ð: IL-6 Àü»çÁ¶ÀýºÎÀ§ÀÇ ´ÜÀÏ¿°±â¼¿´ÙÇü¼ºÀº ÀڱðæºÎ¾ÏÀÇ ¹ß»ý°ú ¿¬°ü¼ºÀ» °®Áö ¾Ê´Â´Ù.
Objective: The aims of this study were to determine whether polymorphisms of the interleukin-6 promoter might be associated with an increased risk of cervical cancer.
Methods: The bloods were obtained from healthy women(n=130), and patients with cervical cancer(n=109). The IL-6 promoter was examined with allele-specific PCR method. The clinical characteristics of patients were compared between two groups.
Results: There is IL-6 -572 SNP. The genotypic distribution in cervical cancer patients were GG genotype 55(50.5%), GC genotype 45(41.3%), CC genotype 9(8.2%). There were no stastistical differences of each genotypes between control group and cervical cancer group.(p>0.05).
Conclusion: Our results suggested that SNP of IL-6 promoter is not related with the carcinogenesis of cervical cancer.
Å°¿öµå
IL-6 Àü»çÁ¶ÀýºÎÀ§, ´ÜÀÏ¿°±â¼¿´ÙÇü¼º, ÀڱðæºÎ¾Ï
Interleukin-6 promoter, Single nucleotide polymorphism, Cervix cancer
KMID :
0388020010120040318
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À¯È¿¼º°á°ú(Recomendation)
SNP of IL-6 promoter is not related with the carcinogenesis of cervical cancer.