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소아암 생존자에서 대사증후군 구성 요소의 유병률
Prevalence of the Components of Metabolic Syndrome in Childhood Cancer Survivors

Clinical Pediatric Hematology-Oncology 2014년 21권 1호 p.23 ~ p.28

신혜경(Shin Hye-Kyung) - 한양대학교 의과대학 소아과학교실
최영진(Choi Young-Jin) - 한양대학교 의과대학 소아과학교실
이영호(Lee Young-Ho) - 한양대학교 의과대학 소아과학교실
신재훈(Shin Jeh-Hoon) - 한양대학교 의과대학 소아과학교실
양승(Yang Seung) - 한림대학교 의과대학 소아과학교실

Abstract

Background: Childhood cancer survivors have been reported to have an increased risk of prevalence of metabolic syndrome compared to the normal population. The purpose of this study was to investigate the prevalence of the components of metabolic syndrome in childhood cancer survivors in a single institute.

Methods: The study included survivors who had survived for at least 5 years after off chemotherapy without evidence of recurrence. We measured body mass index (BMI), triglycerides (TG), high-density lipoprotein (HDL)?cholesterol, systolic and diastolic blood pressure, and fasting glucose.

Results: We investigated 58 childhood cancer survivors, median age 5.4 years (range, 0.1?17.2 years) at diagnosis and median follow-up time elapsed after off chemotherapy 7.4 years (range, 4.7?18.6 years). The frequency of metabolic syndrome was 3.4%. The prevalence of each component was: obesity, 17.2%; elevated TG level, 46.6%; low HDL cholesterol, 34.5%; elevated blood pressure, 1.7%; and elevated fasting glucose, 9.3%, respectively. Sixty nine percentage of survivors had at least 1 abnormal component of metabolic syndrome. The increased TG level was found more frequently in obese sub-jects than normal weight subjects.

Conclusion: We observed the high incidence of increased TG level in childhood cancer survivors. It is necessary to be closely monitored the components of metabolic syndrome in childhood cancer survivors, in order to prevent them from cardiovascular diseases and improve their health outcomes.

키워드

Childhood cancer survivor, Metabolic syndrome

KMID : 0387820140210010023

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주제코드

주제명(Target field)

연구대상(Population)

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대상성별(Gender)

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DOI

KCD코드

ICD 03

건강보험코드

소아암 생존자에서 대사증후군 구성 요소의 유병률 Prevalence of the Components of Metabolic Syndrome in Childhood Cancer Survivors

Abstract

키워드

소아암 생존자에서 대사증후군 구성 요소의 유병률
Prevalence of the Components of Metabolic Syndrome in Childhood Cancer Survivors