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Eleven Years¡¯ Experience with Unexpected Antibody Screening Tests Including a Dia Cell in Transfusion Candidates
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¿Á¼øÁ¤(Ok Soon-Jung) - ºÎ»ê´ëÇб³ ÀÇ°ú´ëÇÐ Áø´Ü°Ë»çÀÇÇб³½Ç
±è½Å¿µ(Kim Shine-Young) - ºÎ»ê´ëÇб³ ÀÇ°ú´ëÇÐ Áø´Ü°Ë»çÀÇÇб³½Ç
±èÀμ÷(Kim In-Suk) - ºÎ»ê´ëÇб³ ÀÇ°ú´ëÇÐ Áø´Ü°Ë»çÀÇÇб³½Ç
ÀÌÀº¿±(Lee Eun-Yup) - ºÎ»ê´ëÇб³ ÀÇ°ú´ëÇÐ Áø´Ü°Ë»çÀÇÇб³½Ç
±èÇüȸ(Kim Hyung-Hoi) - ºÎ»ê´ëÇб³ ÀÇ°ú´ëÇÐ Áø´Ü°Ë»çÀÇÇб³½Ç
Abstract
Background: The Dia antigen has been detected with a relatively higher incidence among the Korean and Southeast Asian population. A ¡¯Type and Screen¡¯ procedure is recommended for efficient transfusion, therefore, we perform antibody screening tests using antibody screening panels containing a Dia cell. The purpose of this study was to report on the experience of unexpected antibody screening test including a Dia cell in the Korean population.
Methods: We analyzed the results of antibody screening testing and identification performed during the recent 11-year period from January 2002 to December 2012. A commercially available three-cell antigen panel (Diacell I, II, Dia; DiaMed, Murten, Switzerland) was used for antibody screening. Antibodies were identified using a LISS/Coombs gel card and NaCl/Enzyme card, using the DiaMed-ID system (DiaMed, Murten, Switzerland).
Results: The frequency of unexpected antibodies was 1.23% (1,918/156,161); the most frequently detected antibodies were anti-E (292 samples), followed by anti-E,c (127 samples), anti-Lea (103 samples), and anti-Dia (91 samples).
Conclusion: Results of this study showed that the most identified unexpected antibodies were clinically significant, and, in particular, anti-Dia antibodies are detected frequently in the Korean population. Thus, unexpected antibody screening test including a Dia cell is thought to be helpful in Korea for safe transfusion.
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Unexpected antibody, Antibody screening test, Anti Dia antibody
KMID :
0387720130240010064
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À¯È¿¼º°á°ú(Recomendation)
Unexpected antibody screening test including a Dia cell is helpful in Korea for safe transfusion; the most identified unexpected antibodies were clinically significant, and, in particular, anti-Dia antibodies are detected frequently in the Korean population.