KCTBASE

의약품 처방·조제지원서비스(Drug Utilization Review)사업이 병용금기 처방률에 미치는 영향
The Effect of Korean Prospective Drug Utilization Review Program on the Prescription Rate of Drug-Drug Interactions

보건행정학회지 2014년 24권 2호 p.120 ~ p.127

김동숙(Kim Dong-Sook) - 건강보험심사평가원 연구조정실
박주희(Park Ju-Hee) - 건강보험심사평가원 연구조정실
전하림(Jeon Ha-Lim) - 건강보험심사평가원 연구조정실
박찬미(Park Chan-Mi) - 건강보험심사평가원 연구조정실
강현아(Kang Hyeun-Ah) - 건강보험심사평가원 연구조정실

Abstract

Background: Since December 2010, online computerized prospective drug utilization review (pDUR) has been implemented in Korea. pDUR involves the review of each prescription before the medication is dispensed to the individual patient. The pDUR is performed electronically by Health Insurance Review & Assessment Service (HIRA), which is a Korean governmental agency, and then HIRA provides medical institutions and pharmacies with information that can be helpful to them in preventing potential drug problems such as drug/drug interactions or ingredient duplication. The aim of this study was to assess the impact of the Korean pDUR implementation on the proportion of drug-drug interactions (DDIs) using claims data from HIRA.

Methods: A before-after comparison of the prevalence of DDIs between prescription was conducted, using HIRA administrative claims data of medical institution from January 2010 to December 2011. The analysis unit was the prescription issued and pairs before and after. The main outcome measures were the proportion of DDIs within- (control group) or between- physician encounters. To examine the difference, a paired t-test was applied.

Results: We found that DDIs proportion between prescription decreased significantly (t=3.04, p=0.0026) after the implementation of pDUR, whereas there is no significant reduction within prescription (t=1.15, p=0.2518). With respect to the prevalence of DDIs between drug groups, the most dramatic reduction was occurred between 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and anti-fungal agents.

Conclusion: It seems effective that giving a direct feedback to prescribers by a prospective DUR. Further research is needed to assess the impact of DUR to final outcomes such as hospitalization.

키워드

Drug utilization review, Drug interaction, Prescription

KMID : 0387320140240020120

원문 및 링크아웃 정보

KISTI

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

의약품 처방·조제지원서비스(Drug Utilization Review)사업이 병용금기 처방률에 미치는 영향 The Effect of Korean Prospective Drug Utilization Review Program on the Prescription Rate of Drug-Drug Interactions

Abstract

키워드

의약품 처방·조제지원서비스(Drug Utilization Review)사업이 병용금기 처방률에 미치는 영향
The Effect of Korean Prospective Drug Utilization Review Program on the Prescription Rate of Drug-Drug Interactions