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병원 밖 심정지 환자에서 저체온 치료 중 시행한 뇌파 양상과 예후의 연관성
The Relationship between EEG Findings and Prognosis in Out-of-Hospital Cardiac Arrest Patients during Therapeutic Hypothermia

대한응급의학회지 2014년 25권 1호 p.1 ~ p.8

이건탁(Lee Gun-Tak) - 성균관대학교 의과대학 삼성서울병원 응급의학과
정가영(Chung Ga-Young) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
이태림(Lee Tae-Rim) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
차원철(Cha Won-Chul) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
신태건(Shin Tae-Gun) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
심민섭(Sim Min-Seob) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
조익준(Jo Ik-Joon) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
송근정(Song Keun-Jeong) - 성균관대학교 의과대학 삼성서울병원 응급의학교실
정연권(Jeong Yeon-Kwon) - 성균관대학교 의과대학 삼성서울병원 응급의학교실

Abstract

Purpose: Prediction of neurologic outcome in survivors after cardiac arrest is difficult. In particular, since therapeutic hypothermia has emerged as the standard treatment for post cardiac arrest syndrome, the prediction has been more difficult. Methods for prediction of neurologic prognosis include the general neurologic examination, SSEPs, EEG, serum biomarkers, and so on. Among these, EEG was recommended for detection of non-convulsive seizure since early phase of post cardiac arrest syndrome. However, the relationship between EEG finding and neurologic outcome is not yet clear.

Methods: We conducted a retrospective observational study using a prospectively collected hypothermia database. We collected EEG findings during hypothermia and other data from January 2010 to December 2012. The EEG findings were classified according to five patterns as extremely low voltage, continuous slow wave, burst suppression, status epilepticus, and other. We analyzed the relationship between EEG pattern and one-month CPC score after cardiac arrest.

Results: During the study period, 121 patients were enrolled in the hypothermia database. Among these patients, 84 patients underwent EEG during hypothermia and were enrolled. The EEG patterns of enrolled patients were 20 extremely low voltage, 39 generalized slow wave, 15 burst suppression, 8 status epilepticus, and 2 alpha coma. None of the periodic, status eplilepticus, and alpha coma pattern patients showed a good neurologic outcome (CPC 1 or 2). Two of 20 extremely low voltage and 28 of 39 continuous slow wave pattern patients recovered to good neurologic outcome.

Conclusion: Burst suppression and status epilepticus EEG pattern during hypothermia treatment showed an association with poor neurologic outcome.

키워드

Cardiac arrest, EEG, Induced hypothermia

KMID : 0385920140250010001

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주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

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질병특성(Condition Category)

연구환경(Setting)

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유효성결과(Recomendation)

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DOI

KCD코드

ICD 03

건강보험코드

병원 밖 심정지 환자에서 저체온 치료 중 시행한 뇌파 양상과 예후의 연관성 The Relationship between EEG Findings and Prognosis in Out-of-Hospital Cardiac Arrest Patients during Therapeutic Hypothermia

Abstract

키워드

병원 밖 심정지 환자에서 저체온 치료 중 시행한 뇌파 양상과 예후의 연관성
The Relationship between EEG Findings and Prognosis in Out-of-Hospital Cardiac Arrest Patients during Therapeutic Hypothermia