Fatal Clinical Course of Probable Invasive Pulmonary Aspergillosis with Influenza B Infection in an Immunocompetent Patient

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¹Úµ¿¿ø(Park Dong-Won) - Hanyang University College of Medicine Department of Internal Medicine
ÀÌÁö¿µ(Yhi Ji-Young) - Hanyang University College of Medicine Department of Internal Medicine
±¸°Ç¿ì(Koo Gun-Woo) - Hanyang University College of Medicine Department of Internal Medicine
Á¤¼ºÁØ(Jung Sung-Jun) - Hanyang University College of Medicine Department of Internal Medicine
°ûÇöÁ¤(Kwak Hyun-Jung) - Hanyang University College of Medicine Department of Internal Medicine
¹®Áö¿ë(Moon Ji-Yong) - Hanyang University College of Medicine Department of Internal Medicine
±è»óÇå(Kim Sang-Heon) - Hanyang University College of Medicine Department of Internal Medicine
±èÅÂÇü(Kim Tae-Hyung) - Hanyang University College of Medicine Department of Internal Medicine
¼ÕÀå¿ø(Sohn Jang-Won) - Hanyang University College of Medicine Department of Internal Medicine
½Åµ¿È£(Shin Dong-Ho) - Hanyang University College of Medicine Department of Internal Medicine
¹Ú¼º¼ö(Park Sung-Soo) - Hanyang University College of Medicine Department of Internal Medicine
À±È£ÁÖ(Yoon Ho-Joo) - Hanyang University College of Medicine Department of Internal Medicine

Abstract

Invasive pulmonary aspergillosis (IPA) is rarely reported in patients who have normal immune function. Recently, IPA risk was reported in nonimmunocompromised hosts, such as patients with chronic obstructive pulmonary disease and critically ill patients in intensive care units. Moreover, influenza infection is also believed to be associated with IPA among immunocompetent patients. However, most reports on IPA with influenza A infection, including pandemic influenza H1N1, and IPA associated with influenza B infection were scarcely reported. Here, we report probable IPA with a fatal clinical course in an immunocompetent patient with influenza B infection. We demonstrate IPA as a possible complication in immunocompetent patients with influenza B infection. Early clinical suspicion of IPA and timely antifungal therapy are required for better outcomes in such cases.

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Invasive Pulmonary Aspergillosis, Influenza B Virus, Immunocompetence
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