A Case of Venlafaxine-Induced Interstitial Lung Disease

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¿À¼¼¸²(Oh Se-Rim) - Kyungpook National University School of Medicine Department of Internal Medicine
Â÷½ÂÀÍ(Cha Seung-Ick) - Kyungpook National University School of Medicine Department of Internal Medicine
±èÇý¶ó(Kim Hye-Ra) - Kyungpook National University School of Medicine Department of Internal Medicine
±è¹ÎÁ¤(Kim Min-Jung) - Kyungpook National University School of Medicine Department of Internal Medicine
ÃÖ¼±ÇÏ(Choi Sun-Ha) - Kyungpook National University School of Medicine Department of Internal Medicine
¼­Çý¿ø(Seo Hye-Won) - Kyungpook National University School of Medicine Department of Internal Medicine
¹ÚÅÂÀÎ(Park Tae-In) - Kyungpook National University School of Medicine Department of Pathology

Abstract

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD.

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Hypersensitivity, Pneumonia, Lung Disease, Interstitial, Venlafaxine
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