Outcomes of Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer in One Institution
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À̼®Á¤(Lee Seok-Jeong) - Ewha Womans University School of Medicine Department of Internal Medicine
°ÇöÁÖ(Kang Hyun-Ju) - Ewha Womans University School of Medicine Department of Internal Medicine
±è¼¿ì(Kim Seo-Woo) - Ewha Womans University School of Medicine Department of Internal Medicine
(Ryu You-Ju) - Ewha Womans University School of Medicine Department of Internal Medicine
ÀÌÁøÈ(Lee Jin-Hwa) - Ewha Womans University School of Medicine Department of Internal Medicine
±èÀ¯°æ(Kim Yoo-Kyung) - Ewha Womans University School of Medicine Department of Radiology
ÀåÁßÇö(Chang Jung-Hyun) - Ewha Womans University School of Medicine Department of Internal Medicine
Abstract
Background: This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC).
Materials and Methods: We retrospectively reviewed the records of 137 patients with inoperable stage III?IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis.
Results: Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020?2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010?5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063?2.203) had higher HR for death.
Conclusion: The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.
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Age Groups, Carcinoma, Non-Small-Cell Lung, Drug Therapy, Survival
KMID :
0383820140770010013
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À¯È¿¼º°á°ú(Recomendation)
Age over 65 years, T4 tumor stage, and poor response to first-line chemotherapy were the most influential predictors of survival after second-line chemotherapy in this study.The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC