Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
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(Md. Asaduzzaman Sikder) - Chungnam National University School of Medicine Department of Pharmacology
ÀÌÇöÀç(Lee Hyun-Jae) - Chungnam National University School of Medicine Department of Pharmacology
·ùÁöÈ£(Ryu Ji-Ho) - Chungnam National University School of Medicine Department of Pharmacology
¹Ú¼öÇö(Park Su-Hyun) - Chungnam National University School of Medicine Department of Pharmacology
±èÁÖ¿Á(Kim Ju-Ock) - Chungnam National University School of Medicine Chungnam National University Hospital Department of Internal Medicine
È«ÀåÈñ(Hong Jang-Hee) - Chungnam National University School of Medicine Department of Pharmacology
¼®Á¤È£(Seok Jeong-Ho) - Chungnam National University School of Medicine Department of Pharmacology
ÀÌÃæÀç(Lee Choong-Jae) - Chungnam National University School of Medicine Department of Pharmacology
Abstract
Background: 1Department of Pharmacology, Chungnam National University School of Medicine, 2Pulmonology Section, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Materials and Methods: Confluent NCI-H292 cells were pretreated with wogonin or apigenin for 15 minutes or 24 hours and then stimulated with epidermal growth factor (EGF) for 24 hours or the indicated periods.
Results: We found that incubation of NCI-H292 cells with wogonin or apigenin inhibited the phosphorylation of EGFR. The downstream signals of EGFR such as phosphorylation of MEK1/2 and ERK1/2 were also inhibited by wogonin or apigenin.
Conclusion: The results suggest that wogonin and apigenin inhibits EGFR signaling pathway, which may explain how they inhibit MUC5AC mucin gene expression and production induced by EGF.
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Receptor, Epidermal Growth Factor, Mucins, Wogonin, Apigenin
KMID :
0383820140760030120
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