A Case of Immunoglobulin G4-Related Disease Presenting as a Pleural Mass
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±èµ¿Çö(Kim Dong-Hyun) - Seoul National University Bundang Hospital Department of Internal Medicine
°í±ÔÇÑ(Koh Kyu-Han) - Seoul National University Bundang Hospital Department of Internal Medicine
¿ÀÇö½Ä(Oh Hyeon-Sik) - Seoul National University Bundang Hospital Department of Pathology
±è¼¼Áß(Kim Se-Joong) - Seoul National University Bundang Hospital Department of Respiratory and Critical Care Medicine
°»õÇÑ(Kang Sae-Han) - Seoul National University Bundang Hospital Department of Internal Medicine
Á¤º´¿í(Jung Byung-Wook) - Seoul National University Bundang Hospital Department of Internal Medicine
¼ÛÁرÔ(Song Jun-Gyu) - Seoul National University Bundang Hospital Department of Internal Medicine
¹Ú¿ë¿ø(Cheon Mi-Ju) - Seoul National University Bundang Hospital Department of Internal Medicine
(Yoon Seon-Bin) - Seoul National University Bundang Hospital Department of Internal Medicine
¹Ú¿ë¿ø(Park Yong-Won) - Seoul National University Bundang Hospital Department of Internal Medicine
°í¿µ¹Î(Ko Young-Min) - Seoul National University Bundang Hospital Department of Internal Medicine
À̽ÂÇö(Lee Seung-Hyeun) - Seoul National University Bundang Hospital Department of Internal Medicine
Abstract
Immunoglobulin G4 (IgG4)-related disease is a newly recognized condition characterized by fibroinflammatory lesions with dense lymphoplasmacytic infiltration, storiform-type fibrosis and obliterative phlebitis. The pathogenesis is not fully understood but multiple immune-mediated mechanisms are believed to contribute. This rare disease can involve various organs and pleural involvement is even rarer. We report a case of IgG4-related disease involving pleura. A 66-year-old man presented with cough and sputum production for a week. Chest radiography revealed consolidation and a pleural mass at right hemithorax. Treatment with antibiotics resolved the consolidation and respiratory symptoms disappeared, but the pleural mass was unchanged. Video-assisted thoracoscopic surgery was performed. Histopathology revealed dense lymphoplasmacytic infiltration and storiform fibrosis with numerous IgG4-bearing plasma cells. The serum IgG4 level was also elevated. Further examination ruled out the involvement of any other organ. The patient was discharged without further treatment and there is no evidence of recurrence to date.
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Immunoglobulin G, Autoimmune Diseases, Pleural Neoplasmslar
KMID :
0383820140760010038
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