The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis
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Á¤º´È£(Jeong Byeong-Ho) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
±è¼ö¿µ(Kim Su-Young) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
Àü°æ¸¸(Jeon Kyeong-Man) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
ÇãÈñÀç(Huh Hee-Jae) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Laboratory Medicine and Genetics
±ââ¼®(Ki Chang-Seok) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Laboratory Medicine and Genetics
À̳²¿ë(Lee Nam-Yong) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Laboratory Medicine and Genetics
½Å¼ºÀç(Shin Sung-Jae) - Yonsei University College of Medicine Department of Microbiology
°í¿øÁß(Koh Won-Jung) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine
Abstract
We report the first Korean case of lung diseases caused by Mycobacterium abscessus subsp. bolletii in a previously healthy male, except for a previous history of pulmonary tuberculosis and bronchiectasis. All serial isolates are identified as M. abscessus subsp. bolletii by multi-locus sequence analysis based on the hsp65, rpoB, and 16S rRNA fragments. At the genetic level, the isolate has the erm(41) gene with a T28 sequevar, associated with clarithromycin resistance, and no rrl mutation. The isolate is resistant to clarithromycin. Although the symptoms and radiographic findings have improved after combination of antibiotics, the follow-up sputum cultures are persistently positive.
Å°¿öµå
Bronchiectasis, Mycobacterium Infections, Nontuberculous, Nontuberculous Mycobacteria, Sequence Analysis, DNA
KMID :
0383820140760010030
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