Clinical Features and Prognostic Factors in Elderly Koreans with Advanced Non-Small-Cell Lung Cancer in a Tertiary Referral Hospital
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±è¼¿ì(Kim Seo-Woo) - Ewha Womans University School of Medicine Department of Internal Medicine
±è¹Ì¿¬(Kim Mi-Yeon) - Ewha Womans University School of Medicine Department of Internal Medicine
ÀÌÀ±Ç¥(Lee Yoon-Pyo) - Ewha Womans University School of Medicine Department of Internal Medicine
·ù¿¬ÁÖ(Ryu Yon-Ju) - Ewha Womans University School of Medicine Department of Internal Medicine
À̼®Á¤(Lee Seok-Jeong) - Ewha Womans University School of Medicine Department of Internal Medicine
ÀÌÁøÈ(Lee Jin-Hwa) - Ewha Womans University School of Medicine Department of Internal Medicine
ÀåÁßÇö(Chang Jung-Hyun) - Ewha Womans University School of Medicine Department of Internal Medicine
½É¼º½Å(Shim Sung-Shine) - Ewha Womans University School of Medicine Department of Radiology
Abstract
Background : More than half of cases for advanced non-small-cell lung cancer (NSCLC) occur in elderly patients with a median age at diagnosis of 70 years. The aim of our study was to examine the clinical features and prognostic factors contributing to mortality in elderly patients with advanced NSCLC. Materials and Methods : Following a retrospective review of clinical data, 122 patients aged 70 years and over with a histopathological diagnosis of locally advanced (stage IIIB, n=32) and metastatic (stage IV, n=90) NSCLC between 2005 and 2011 were enrolled. Results : The median age was 76 years (interquartile range, [IQR], 72?80 years), and 85 (70%) patients were male. Fifty-seven (46%) patients had never smoked, and 17 (19%) were in a malnourished state with a body mass index (BMI) of <18.5 kg/m2. The initial treatments included chemotherapy (40%) and radiotherapy (7%), but 57% of the patients received supportive care only. The 1-year survival rate was 32%, and the 3-year survival rate was 4%, with a median survival duration of 6.2 months (IQR, 2.5?15.3 months). Male gender (hazard ratio [HR], 2.2; 95% confidence interval [CI], 1.3?3.9; p=0.005), low BMI (HR, 2.3; 95% CI, 1.3?3.9; p=0.004), and supportive care only (HR, 1.9; 95% CI, 1.2?2.9; p=0.007) were independent predictors of shorter survival based on a Cox proportional hazards model. Conclusion : Elderly patients with advanced NSCLC had a poor prognosis, particularly male patients, those with a low BMI, and those who received supportive care only.
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Carcinoma, Non-Small-Cell Lung, Aged, Prognosis, Mortality
KMID :
0383820130750020052
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¤Ánitial treatments included chemotherapy (40%) and radiotherapy (7%), but 57% of the patients received supportive care only. The 1-year survival rate was 32%, and the 3-year survival rate was 4%, with a median survival duration of 6.2 months (IQR, 2.5?15.3 months). Elderly patients with advanced NSCLC had a poor prognosis, particularly male patients, those with a low BMI, and those who received supportive care only.