비소세포 폐암환자에서 Docetaxel 투여 중 발생한 아급성 피부 홍반루푸스 1예
A Case of Docetaxel Induced Subacute Cutaneous Lupus Erythematosus
결핵및호흡기질환 2009년 66권 5호 p.380 ~ p.384
신정아(Shin Jung-Ar) - 연세대학교 의과대학 내과학교실
허철웅(Huh Cheal-Wung) - 연세대학교 의과대학 내과학교실
권지은(Kwon Ji-Eun) - 연세대학교 의과대학 진단병리학교실
김형중(Kim Hyung-Jung) - 연세대학교 의과대학 내과학교실
안철민(Ahn Chul-Min) - 연세대학교 의과대학 내과학교실
장윤수(Chang Yoon-Soo) - 연세대학교 의과대학 내과학교실
Abstract
Drug-induced subacute cutaneous lupus erythematosus (SCLE) is associated with use of the following classes of medications: anti-hypertensives, anti-cholesterolemia, anti-psychotics, and anti-inflammatory drugs. Docetaxel is an anti-neoplastic agent, which is widely used for treatment of non-small cell lung cancer. Few cases of docetaxel-induced SCLE have been reported in the medical literature. Here, we report the case of a 58-year-old female patient who developed drug-induced SCLE after administration of docetaxel. After 4 cycles of chemotherapy with docetaxel and cisplatin, erythematous skin eruptions developed on the patient’s face. Skin biopsies of the eruptions were remarkable for interfacing dermatitis with basement membrane thickening. Immunofluorescent study revealed characteristic features of SCLE, including granular deposition of IgM, C3, and apoptotic bodies along the basement membrane. The skin eruptions resolved gradually after cessation of drug and with the use of topical corticosteroids.
키워드
Subacute cutaneous lupus erythematosus, Drug-induced lupus erythematosus, Non-small-cell lung carcinoma, Docetaxel
KMID :
0383820090660050380
원문 및 링크아웃 정보
등재저널 정보
유효성결과(Recomendation)
drug-induced subacute cutaneous lupus erythematosus (SCLE) after administration of docetaxel