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A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Chemotherapy in a Patient with Non-Small-Cell Lung Cancer
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ÀÌ°æÁÖ(Lee Kyung-Joo) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
À̼º¿ë(Lee Sung-Yong) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
ÀÌ»ó¿±(Lee Sang-Yeub) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
±èÁ¦Çü(Kim Je-Hyeong) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
½Åö(Shin Chol) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
½ÉÀçÁ¤(Shim Jae-Jeong) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Àα¤È£(In Kwang-Ho) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
°°æÈ£(Kang Kyung-Ho) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
À¯¼¼È(Yoo Se-Hwa) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
¹®À翵(Moon Jae-Young) - °í·Á´ëÇб³ ÀÇ°ú´ëÇÐ ³»°úÇб³½Ç
Abstract
The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic
phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.
Å°¿öµå
Inappropriate ADH syndrome, Non-small-cell Lung carcinoma, Hyponatremia, Carboplatin
KMID :
0383820090660040324
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À¯È¿¼º°á°ú(Recomendation)
carboplatin & Gemcitabine combination ºÎÀÛ¿ëÀ¸·Î secretion of the antidiuretic hormone (SIADH)·Î Áø´Ü¹Þ°í carboplatin ¾àÁ¦ Áß´Ü ÈÄ È£Àü