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局所進行된 非小細胞肺癌의 etoposide와 cisplatin(EP) 先行化學療法과 放射線竝用治療
Neoadjuvant Chemotherapy with Etoposide and Cisplatin(EP) plus Radiotherapy in Locally Advanced Nonsmall Cell Lung Cancer

한국생활과학연구원논총 1991년 48권 0호 p.95 ~ p.102

이순남(Lee Soon-Nam) - 이화여자대학교 의과대학 내과학교실

Abstract

The author treated 17 patients with locally advanced nonsmall cell lung cancer with combined chemotherapy and radiotherapy from Mar. 1989 to May. 1991.

Neoadjuvant chemotherapy was performed with 3 cycles of etoposide(VP-16) 100㎎/㎡ IV on days 1-5 and cisplatin 20㎎/㎡ IV on days 1-5 at interval of 3-4 weeks.

Then radiotherapy to primary tumor, mediastinum and both supraclavicular lymph nodes was followed by.

The results obtained were as follows :

1) After neoadjuvant chemotherapy with EP, partial remission rate was 41.1％ without complete remission. At completion of radiotherapy, complete remission rate was 35.3％ and partial remission rate was 41.1％(Overall response rate was 76.4％).

2) The median survival of all patients was 15.9 months. For responder of EP chemotherapy, median suvival was 20 months and 10 months for nonresponders. The median survival of complete responders at completion of radiotherapy was 21.8 months and of partial responders was 9.8 months (p>0.1). Overall survival rate at 1 and 2 year was 64.3％ and 24.4％ respectively.

3) The treatment toxicities were mainly nausea, vomiting and alopecia in all patients. The hematologic toxicities were 5％ of agranulocytosis and 2.5％ of thrombocytopenia. But there was no treatment related death. With radiotherapy, irreversible radiation pneumonitis was frequent(35.3％).

In conclusion, EP chemotherapy followed by radiotherapy can increase the response rate of the locally advanced nonsmall cell lung cancer and prolong the survival of those patients. But confirmatory tests of prospective randomized trial should be followed to confirm the role of neoadjuvant chemotherapy and more active combinations of drugs and new treatment modalities should be investigated further.

키워드

KMID : 0380319910480000095

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주제코드

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연구대상(Population)

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유효성결과(Recomendation)

Etoposide and Cisplatin(EP) chemotherapy followed by radiotherapy can increase the response rate of the locally advanced nonsmall cell lung cancer and prolong the survival of those patients.

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DOI

KCD코드

ICD 03

건강보험코드

局所進行된 非小細胞肺癌의 etoposide와 cisplatin(EP) 先行化學療法과 放射線 竝用治療 Neoadjuvant Chemotherapy with Etoposide and Cisplatin(EP) plus Radiotherapy in Locally Advanced Nonsmall Cell Lung Cancer

Abstract

키워드

局所進行된 非小細胞肺癌의 etoposide와 cisplatin(EP) 先行化學療法과 放射線竝用治療
Neoadjuvant Chemotherapy with Etoposide and Cisplatin(EP) plus Radiotherapy in Locally Advanced Nonsmall Cell Lung Cancer