Hereditary protein S deficiency presenting acute pulmonary embolism
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±èÁö¿Ï(Kim Ji-Wan) - Konkuk University School of Medicine Department of Cardiovascular Medicine
±è¼ºÇØ(Kim Sung-Hea) - Konkuk University School of Medicine Department of Cardiovascular Medicine
Á¤»ó¸¸(Jung Sang-Man) - Konkuk University School of Medicine Department of Cardiovascular Medicine
¹Ú¼ö¿¬(Park Soo-Youn) - Konkuk University School of Medicine Department of Cardiovascular Medicine
À¯Çü¹Î(Yu Hyung-Min) - Konkuk University School of Medicine Department of Cardiovascular Medicine
¾È»óÈñ(An Sang-Hee) - Konkuk University School of Medicine Department of Cardiovascular Medicine
°¼ºÈñ(Kang Seong-Hui) - Konkuk University School of Medicine Department of Cardiovascular Medicine
±èÇöÁß(Kim Hyun-Joong) - Konkuk University School of Medicine Department of Cardiovascular Medicine
Abstract
Protein S deficiency is one of the several risk factors for thrombophilia and can cause blood clotting disorders such as deep vein thrombosis and pulmonary embolism. A 54-year-old man was admitted with the complaint of dyspnea and was diagnosed with pulmonary embolism. The patient had very low level of free protein S, total protein S antigen, and protein S activity (type I protein S deficiency). In history taking, we found that his mother, 78 year old, had a history of same disease 10 years ago, and confirmed the pronounced low level of protein S. The patient¡¯s son also had very low level of protein S, however there had not been any history of pulmonary embolism yet. This case study suggests that asymptomatic persons with a family history of protein S deficiency and pulmonary embolism should be checked regularly for early detection of the disease, as protein S deficiency can be suspected.
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Pulmonary embolism, Protein S deficiency, Family history
KMID :
0370920140310010052
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