Higher Blood Pressure Variability in White Coat Hypertension; from the Korean Ambulatory Blood Pressure Monitoring Registry
Korean Circulation Journal 2016³â 46±Ç 3È£ p.365 ~ p.373
°Àμ÷(Kang In-Sook) - Yonsei University College of Medicine Department of Internal Medicine
Æí¿í¹ü(Pyun Wook-Bum) - Ewha Womans University School of Medicine Department of Internal Medicine
½ÅÁøÈ£(Shin Jin-Ho) - Hanyang University College of Medicine Department of Internal Medicine
ÀÓ»óÇö(Ihm Sang-Hyun) - Catholic University College of Medicine Department of Internal Medicine
±èÁÖÇÑ(Kim Ju-Han) - Chonnam National University School of Medicine Department of Internal Medicine
¹Ú¼ºÇÏ(Park Sung-Ha) - Yonsei University College of Medicine Department of Internal Medicine
±è±¤ÀÏ(Kim Kwang-Il) - Seoul National University College of Medicine Department of Internal Medicine
±è¿ì½Ä(Kim Woo-Shik) - Kyung Hee University School of Medicine Department of Internal Medicine
Abstract
Background and Objectives: Blood pressure variability (BPV) was recently shown to be a risk factor of stroke. White coat hypertension (WCH) used to be regarded as innocuous, but one long-term follow-up study reported that WCH increased stroke rate compared to normotension (NT). In this study, we aimed to evaluate the relationship between WCH and BPV.
Subjects and Methods: We analyzed 1398 subjects from the Korean Ambulatory Blood Pressure Registry, who were divided into NT (n=364), masked hypertension (n=122), white coat hypertension (n=254), and sustained hypertension (n=658) groups.
Results: Baseline characteristics were similar among groups. The average real variability (ARV), a highly sensitive BPV parameter, was highest in the WCH group, followed by the sustained hypertension, masked hypertension, and NT groups. The results persisted after being adjusted for covariates. The WCH vs. sustained hypertension results (adjusted mean¡¾standard error) were as follows: 24-h systolic ARV, 22.9¡¾0.8 vs. 19.4¡¾0.6; 24-h diastolic ARV, 16.8¡¾0.6 vs. 14.3¡¾0.5; daytime systolic ARV, 21.8¡¾0.8 vs. 16.8¡¾0.6; and daytime diastolic ARV, 16.2¡¾0.6 vs. 13.4¡¾0.5 (p<0.001 for all comparisons).
Conclusion: From the registry data, we found that subjects with WCH or masked hypertension had higher BPV than NT. However, long-term follow-up data assessing the clinical influences of WCH on stroke are needed.
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Blood pressure monitoring, Ambulatory, Blood pressure variability, White coat hypertension
KMID :
0368120160460030365
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Patients with WCH or masked hypertension had higher BPV than normotension (NT).