Clinical Outcomes in Patients with Intermediate Coronary Stenoses: MINIATURE Investigators (Korea MultIceNter TrIal on Long-Term Clinical Outcome According to the Plaque Burden and Treatment Strategy in Lesions with MinimUm Lumen ARea lEss Than 4 mm2 Using Intravascular Ultrasound)
Korean Circulation Journal 2014³â 44±Ç 3È£ p.148 ~ p.155
È«¿µÁØ(Hong Young-Joon) - Chonnam National University Hospital Department of Cardiology
ÃÖÀ±ÇÏ(Choi Yun-Ha) - Chonnam National University School of Medicine Division of Cardiology
¹Ú¼ö¿µ(Park Soo-Young) - Chonnam National University School of Medicine Division of Cardiology
³²Ã¢¿í(Nam Chang-Wook) - Keimyung University College of Medicine Dongsan Medical Center Department of Internal Medicine
Á¶ÀåÇö(Cho Jang-Hyun) - Saint Carollo Hospital Division of Cardiology
ÀÌ»ó·Ï(Lee Sang-Rok) - Jeonbuk National University Medical School Department of Internal Medicine
À̼ºÀ±(Lee Sung-Yun) - Inje University College of Medicine Department of Internal Medicine
±è»ó¿í(Kim Sang-Wook) - Chung-Ang University College of Medicine Department of Internal Medicine Division of Cardiology
(Lim Sang-Yeob) - Korea University Ansan Hospital Department of Internal Medicine Division of Cardiology
À±°æÈ£(Yun Kyung-Ho) - Wonkwang University College of Medicine Division of Cardiology
±èÁß¼±(Kim Jung-Sun) - Yonsei University College of Medicine Severance Cardiovascular Hospital Division of Cardiology
±èÁø¿ø(Kim Jin-Won) - Korea University Guro Hospital Cardiovascular Center
°¿õö(Kang Woong-Chol) - Gachon University Gill Hospital Department of Cardiology
±è±â¼®(Kim Ki-Seok) - Jeju National University College of Medicine Department of Medicine
ÃÖÁøÈ£(Choi Jin-Ho) - Sungkyunkwan University College of Medicine Samsung Medical Center Department of Cardiology
±è¼öÁß(Kim Soo-Joong) - Kyung Hee University School of Medicine Department of Cardiology
Á¤ÁßÈ(Chung Joong-Wha) - Chosun University College of Medicine Division of Cardiology
¾È¿µ±Ù(Ahn Young-Keun) - Chonnam National University Hospital Department of Cardiology
Á¤¸íÈ£(Jeong Myung-Ho) - Chonnam National University Hospital Department of Cardiology
°¿øÀ¯(Kang Won-Yu) - Gwangju Veterans Hospital Department of Internal Medicine Division of Cardiology
Abstract
Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy.
Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE).
Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034).
Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden.
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Coronary artery disease, Atherosclerotic plaque, Intravascular ultrasonography
KMID :
0368120140440030148
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