A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
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º¯¿µÀç(Byun Young-Jae) - Hanyang University College of Medicine Department of Internal Medicine
¹Úº´¹è(Park Byeong-Bae) - Hanyang University College of Medicine Department of Internal Medicine
ÀÌÀº¼º(Lee Eun-Sung) - Hanyang University College of Medicine Department of Internal Medicine
ÃÖ°æ¼ö(Choi Kyung-Soo) - Hanyang University College of Medicine Department of Internal Medicine
À̴뼺(Lee Dae-Sung) - Hanyang University College of Medicine Department of Internal Medicine
Abstract
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by over-production of myeloid white blood cells. Philadelphia chromosome is an essential finding for CML diagnosis. Generally, a clinical diagnosis of essential thrombocythemia (ET) can be established from isolated marked thrombocytosis in peripheral blood. However, Philadelphia chromosome-positivity or bcr/abl rearrangement with isolated thrombocy-tosis should be diagnosed as CML, not ET, according to World Health Organization diag-nostic criteria. Therefore, CML should not be excluded before confirming the presence of the Philadelphia chromosome or bcr/abl rearrangement in cases of isolated thrombocy-tosis in peripheral blood. We report a case of CML with clinical features of ET in a patient successfully treated with imatinib.
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Chronic myeloid leukemia, Philadelphia chromosome, Essential thrombocythemia
KMID :
0366220140490020127
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