A case of oxaliplatin-induced immune-mediated thrombocytopenia
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¼¼ºÀº(Suh Seong-Eun) - CHA University School of Medicine Department of Internal Medicine
Àå¹®ÁÖ(Jang Moon-Ju) - CHA University School of Medicine Department of Internal Medicine
Á¤¼Ò¿µ(Chong So-Young) - CHA University School of Medicine Department of Internal Medicine
(Richard H. Aster) - Blood Center of Wisconsin Platelet & Neutrophil Immunology Laboratory
(Brian R. Curtis) - Blood Center of Wisconsin Platelet & Neutrophil Immunology Laboratory
¿Àµµ¿¬(Oh Do-Yeun) - CHA University School of Medicine Department of Internal Medicine
Abstract
Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-in-duced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemo-therapy with oxaliplatin.
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Oxaliplatin, Thrombocytopenia, Immune, Drug-dependent platelet antibody
KMID :
0366220140490010061
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