미숙아의 갑상선 기능 선별검사와 연관된 주산기 인자
Perinatal Factors Associated with the Preterm Thyroid Screening Test

대한주산의학회잡지 2016년 27권 1호 p.45 ~ p.52

박주형(Park Joo-Hyung) - 가톨릭대학교 의과대학 소아과학교실
문청준(Moon Cheong-Jun) - 가톨릭대학교 의과대학 소아과학교실
정민호(Jung Min-Ho) - 가톨릭대학교 의과대학 소아과학교실
성인경(Sung In-Kyung) - 가톨릭대학교 의과대학 소아과학교실
김소영(Kim So-Young) - 가톨릭대학교 의과대학 소아과학교실

Abstract

Purpose: The aim of this study was to evaluate the usefulness of thyroid function screening in preterm infants and the relation between thyroid hormone level, perinatal environment, and clinical presentation after preterm birth.

Method: We retrospectively evaluated 46 preterm infants from March 2013 to December 2014, who had been screened for congenital hypothyroidism during the 1st week with thyroid stimulating hormone (TSH), triiodothyronine (T3) and free thyroxine (fT4) measured by the radioimmunoassay method. The effects of pregnancy associated maternal factors, gestational age, growth parameters, Apgar score, 1st meconium passage time, respiratory distress syndrome and apnea on thyroid hormone levels were assessed by Mann-Whitney U-test and multiple linear regression analysis.

Results: With advancing gestational age, T3 and fT4 displayed a tendency to increase. FT4 showed a positive correlation pattern with antenatal steroid therapy, corrected gestational age at examination and a negative correlation pattern with 1st meconium passage time and apnea (P<0.05). TSH displayed a positive correlation pattern with 1st meconium passage time, 5-minute Apgar score and a negative correlation pattern with sampling age (P<0.05).

Conclusion: In the preterm period, both fT4 and TSH seems to correlate significantly with various perinatal factors and clinical presentation. We recommend that early fT4 screening should be included in the screening for hypothyroidism in preterm infants.

키워드

Prematurity, Thyroid hormones, Thyroxine, Triiodothyronine, Thyrotropin
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등재저널 정보
학술진흥재단(KCI) KoreaMed 대한의학회 회원 
주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Early fT4 screening should be included in the screening for hypothyroidism in preterm infants.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
KCD코드
ICD 03
건강보험코드