Interhemispheric Modulation of Dual-Mode, Noninvasive Brain Stimulation on Motor Function
´ëÇÑÀçÈ°ÀÇÇÐȸÁö 2014³â 38±Ç 3È£ p.297 ~ p.303
¹ÚÀºÈñ(Park Eun-Hee) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical and Rehabilitation Medicine
±èÀ±Èñ(Kim Yun-Hee) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical and Rehabilitation Medicine
Àå¿øÇõ(Chang Won-Hyuk) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical and Rehabilitation Medicine
(Kwon Tae-Gun) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical and Rehabilitation Medicine
½Å¿ëÀÏ(Shin Yong-Il) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical and Rehabilitation Medicine
Abstract
Objective: To investigate the effects of simultaneous, bihemispheric, dual-mode stimulation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) on motor functions and cortical excitability in healthy individuals.
Methods: Twenty-five healthy, right-handed volunteers (10 men, 15 women; mean age, 25.5 years) were enrolled. All participants received four randomly arranged, dual-mode, simultaneous stimulations under the following conditions: condition 1, high-frequency rTMS over the right primary motor cortex (M1) and sham tDCS over the left M1; condition 2, high-frequency rTMS over the right M1 and anodal tDCS over the left M1; condition 3, high-frequency rTMS over the right M1 and cathodal tDCS over the left M1; and condition 4, sham rTMS and sham tDCS. The cortical excitability of the right M1 and motor functions of the left hand were assessed before and after each simulation.
Results: Motor evoked potential (MEP) amplitudes after stimulation were significantly higher than before stimulation, under the conditions 1 and 2. The MEP amplitude in condition 2 was higher than both conditions 3 and 4, while the MEP amplitude in condition 1 was higher than condition 4. The results of the Purdue Pegboard test and the box and block test showed significant improvement in conditions 1 and 2 after stimulation.
Conclusion: Simultaneous stimulation by anodal tDCS over the left M1 with high-frequency rTMS over the right M1 could produce interhemispheric modulation and homeostatic plasticity, which resulted in modulation of cortical excitability and motor functions.
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Bihemispheric stimulation, Transcranial direct current stimulation (tDCS), Transcranial magnetic stimulation (TMS), Interhemispheric modulation, Motor function
KMID :
0361420140380030297
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