Clinical Features and Associated Abnormalities in Children and Adolescents With Corpus Callosal Anomalies
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(Kim Young-Uhk) - Yonsei University College of Medicine Department of Rehabilitation Medicine
¹ÚÀº¼÷(Park Eun-Sook) - Yonsei University College of Medicine Department of Rehabilitation Medicine
Á¤¼öÁø(Jung Soo-Jin) - Yonsei University College of Medicine Department of Rehabilitation Medicine
¼¹Ì¸®(Suh Mi-Ri) - Yonsei University College of Medicine Department of Rehabilitation Medicine
ÃÖÈ¿¼±(Choi Hyo-Seon) - Yonsei University College of Medicine Department of Rehabilitation Medicine
³ªµ¿¿í(Rha Dong-Wook) - Yonsei University College of Medicine Department of Rehabilitation Medicine
Abstract
Callosal anomalies are frequently associated with other central nervous system (CNS) and/or somatic anomalies. We retrospectively analyzed the clinical features of corpus callosal agenesis/hypoplasia accompanying other CNS and/or somatic anomalies. We reviewed the imaging and clinical information of patients who underwent brain magnetic resonance imaging in our hospital, between 2005 and 2012. Callosal anomalies were isolated in 13 patients, accompanied by other CNS anomalies in 10 patients, associated with only non-CNS somatic anomalies in four patients, and with both CNS and non-CNS abnormalities in four patients. Out of 31 patients, four developed normally, without impairments in motor or cognitive functions. Five of nine patients with cerebral palsy were accompanied by other CNS and/or somatic anomalies, and showed worse Gross Motor Function Classification System scores, compared with the other four patients with isolated callosal anomaly. In addition, patients with other CNS anomalies also had a higher seizure risk.
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Callosal agenesis, Gross motor function
KMID :
0361420140380010138
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