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Comparison of Dorzolamide-Timolol Fixed Combination and Latanoprost, Effects on Intraocular Pressure and Ocular Pulse Amplitude
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À̸¶ºó(Lee Mar-Vin) - ºÐ´çÁ¦»ýº´¿ø ¾È°ú
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Abstract
¸ñÀû: µµÁ¹¶ó¹Ìµå-Ƽ¸ô·Ñ º¹ÇÕÁ¦Á¦(dorzolamide-timolol fixed combination, DTFC)¿Í ¶óŸ³ëÇÁ·Î½ºÆ® Á¡¾È ÀüÈÄ ¾È¾Ð°ú ocular pulse amplitude (OPA)ÀÇ º¯È·®À» ºñ±³ÇÏ°íÀÚ ÇÏ¿´´Ù.
´ë»ó°ú ¹æ¹ý: °³¹æ°¢ ³ì³»Àå ȤÀº ³ì³»Àå ÀÇÁõÀ¸·Î Áø´ÜµÈ ȯÀÚ 60¸í 60¾ÈÀ» ´ë»óÀ¸·Î ÇÏ¿´´Ù. DTFC ±º(30¾È)°ú ¶óŸ³ëÇÁ·Î½ºÆ® ±º (30¾È)À¸·Î ³ª´©¾î ¾à¹° »ç¿ë Àü ¾È¾Ð°ú OPA¸¦ °ñµå¸¸¾ÐÆò¾È¾Ð°è(Goldmann applanation tonometer, GAT) ¹× Dynamic contour tonometer (DCT)¸¦ ÀÌ¿ëÇÏ¿© ÃøÁ¤ÇÏ°í ¾à¹°À» Áö¼ÓÀûÀ¸·Î Åõ¿©ÇÑ µÚ ÃÖ¼Ò 1´Þ ÀÌ»ó °æ°úÇÑ ÈÄÀÇ ÃøÁ¤Ä¡¿Í ºñ±³ÇÏ¿´´Ù.
°á°ú: DTFC »ç¿ë ÈÄ GAT ¾È¾Ð, DCT ¾È¾Ð, ¾È±¸¹Úµ¿Å©±âÀÇ Æò±Õ °¨¼Ò·®Àº ¼ø¼´ë·Î 2.25 ¡¾ 2.23 mmHg, 1.97 ¡¾ 2.06 mmHg, 0.14 ¡¾ 0.88 mmHg¿´À¸¸ç ¶óŸ³ëÇÁ·Î½ºÆ® »ç¿ë±ºÀÇ °æ¿ì´Â 2.74 ¡¾ 2.96 mmHg, 2.06 ¡¾ 3.50 mmHg, 0.69 ¡¾ 1.07 mmHg¿´´Ù. DTFC´Â ¶óŸ³ëÇÁ·Î½ºÆ®¿Í ºñ±³ÇÏ¿´À» ¶§ ¾È¾Ð ÇÏ°Á¤µµ¿¡´Â Â÷ÀÌ°¡ ¾ø¾úÀ¸³ª(p=0.311) ¾È±¸¹Úµ¿Å©±âÀÇ ÇÏ° Á¤µµ´Â À¯ÀÇÇÏ°Ô Àû¾ú´Ù(p=0.032).
°á·Ð: DTFC¿Í ¶óŸ³ëÇÁ·Î½ºÆ® »ç¿ë ÀüÈÄ ´Ü±â°£ÀÇ ¾È¾Ð ÇÏ°¿¡´Â À¯ÀÇÇÑ Â÷ÀÌ°¡ ¾ø¾úÀ¸³ª OPA´Â ¶óŸ³ëÇÁ·Î½ºÆ® ±º°ú ´Þ¸® DTFC ±º¿¡
¼´Â À¯ÀÇÇÑ ÇÏ°ÀÌ °üÂûµÇÁö ¾Ê¾ÒÀ¸¸ç ±× ÇÏ° Á¤µµµµ DTFC »ç¿ë±ºÀÌ ¶óŸ³ëÇÁ·Î½ºÆ® »ç¿ë±º¿¡ ºñÇØ À¯ÀÇÇÏ°Ô ÀûÀº °ÍÀ¸·Î ³ªÅ¸³µ´Ù.
Purpose: To compare dorzolamide-timolol fixed combination (DTFC) and latanoprost with regard to their effects on intraocular pressure (IOP) and ocular pulse amplitude (OPA).
Methods: Sixty eyes of 60 patients with open angle glaucoma or glaucoma suspect were included in the present study. Patients were divided into 2 groups, DTFC-treated (n = 30) and latanoprost-treated (n = 30). IOP and OPA were measured with dynamic contour tonometer (DCT) and Goldmann applanation tonometer (GAT), before and at least 1 month after treatment.
Results: GAT IOP, DCT IOP and OPA decreased by 2.25 ¡¾ 2.23 mm Hg, 1.97 ¡¾ 2.06 mm Hg, and 0.14 ¡¾ 0.88 mm Hg, respectively in the DTFC-treated group. In the latanoprost-treated group, GAT IOP, DCT IOP and OPA was reduced by 2.74 ¡¾ 2.96 mm Hg, 2.06 ¡¾ 3.50 mm Hg, and 0.69 ¡¾ 1.07 mm Hg, respectively. There was no significant difference (p = 0.311) in the decline of IOP between the 2 groups, but OPA of the DTFC-treated group decreased less than the latanoprost-treated group (p = 0.032).
Conclusions: No significant differences were observed in the short-term decline of IOP between the 2 medications. However, the influence of DTFC on OPA appeared negligible in the latanoprost-treated group.
Å°¿öµå
Dorzolamide-timolol fixed combination, Dynamic contour tonometer, Intraocular pressure, Latanoprost, Ocular pulse amplitude
KMID :
0360220140550060854
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