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Clinical Manifestations of Ocular Syphilis Combined with Neurosyphilis
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Á¶¿ë¿î(Cho Yong-Wun) - °æ»ó´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ¾È°úÇб³½Ç
±èü·Ð(Kim Che-Ron) - °æ»ó´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ¾È°úÇб³½Ç
Çѿ뼷(Han Yong-Seop) - °æ»ó´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ¾È°úÇб³½Ç
Á¤Àοµ(Chung In-Young) - °æ»ó´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ¾È°úÇб³½Ç
¹ÚÁ¾¹®(Park Jong-Moon) - °æ»ó´ëÇб³ ÀÇÇÐÀü¹®´ëÇпø ¾È°úÇб³½Ç
Abstract
¸ñÀû: Æ÷µµ¸·¿°ÀÇ ÀÓ»ó ¾ç»óÀ¸·Î ¹ßÇöµÇ¾î ¾È°ú Àǻ翡 ÀÇÇØ óÀ½ Áø´ÜµÈ ½Å°æ¸Åµ¶°ú ¿¬°üµÇ¾î ¹ß»ýÇÑ ¾È¸Åµ¶ÀÇ ¹ß»ýÀ» º¸°íÇϰíÀÚ ÇÑ´Ù.
´ë»ó°ú ¹æ¹ý: 2009³â¿¡¼ 2012³â »çÀÌ¿¡ »ïÂ÷ ÀÇ·á ±â°ü¿¡¼ ¹ß»ýÇÑ ¾È¸Åµ¶ ȯÀÚ 7¸í¿¡ °üÇÑ ÈÄÇâÀû ¿¬±¸ÀÌ´Ù.
°á°ú: ȯÀÚµéÀÇ Æò±Õ ¿¬·ÉÀº 44.4¼¼(¹üÀ§ 33-71)¿´´Ù. ¸ðµç ȯÀÚ¿¡¼ ÈľȺÎÀÇ Ä§¹üÀÌ ¹ß°ßµÇ¾úÀ¸¸ç, µÎ ¸íÀº À¯µÎ¿°µµ µ¿¹ÝÇÏ¿´´Ù. Ç÷û °Ë»ç¿¡¼ ¸ðµç ȯÀÚµéÀº VDRL°Ë»ç(Venereal Disease Research Laboraroy), Çü±¤Æ®·¹Æ÷³×¸¶Ç×üÈí¼ö½ÃÇè(FTA-ABS), Æ®·¹Æ÷³×¸¶ ÆÈ¸®µÒÇ÷±¸ÀÀÁý¹ÝÀÀ(TPHA)¿¡¼ ¾ç¼º ¼Ò°ßÀ» º¸¿´´Ù. Çü±¤ ¾ÈÀú°Ë»ç¿¡¼´Â ¸Á¸· Ç÷°ü°ú À¯µÎÀÇ ´©Ãâ ¼Ò°ßÀÌ °¡Àå ÈçÇÑ ¼Ò°ßÀ̾ú´Ù. 6¸íÀÇ È¯ÀÚ¿¡¼ ³úô¼ö¾× °Ë»ç°¡ ÇàÇØÁ³À¸¸ç, ¸ðµÎ ³úô¼ö¾× Çü±¤Æ®·¹Æ÷³×¸¶Ç×üÈí¼ö½ÃÇè°ú Æ®·¹Æ÷³×¸¶ ÆÈ¸®µÒÇ÷±¸ÀÀÁý¹ÝÀÀ¿¡¼ ¾ç¼º ¼Ò°ßÀ» º¸¿´´Ù. ³úô¼ö¾×ÀÇ VDRL°Ë»ç´Â µÎ ¸íÀÇ È¯ÀÚ(33.3%)¿¡¼¸¸ ¾ç¼º ¼Ò°ßÀ̾ú´Ù.
°á·Ð: ¸ðµç ¾È¸Åµ¶ ȯÀÚ´Â ³úô¼ö¾×ÀÇ Çü±¤Æ®·¹Æ÷³×¸¶Ç×üÈí¼ö½ÃÇè°ú Æ®·¹Æ÷³×¸¶ ÆÈ¸®µÒÇ÷±¸ÀÀÁý¹ÝÀÀ¿¡ ÀÇÇØ ½Å°æ¸Åµ¶À¸·Î Áø´ÜµÇ¾ú´Ù. µû¶ó¼ ÀÌ ¿¬±¸¸¦ ÅëÇØ ¾È°ú Àǻ簡 ¸Åµ¶ÀÇ Á¶±â Áø´Ü°ú Ä¡·á¿¡ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù´Â °ÍÀ» ¾Ë ¼ö ÀÖ´Ù.
Purpose: To report the manifestation of ocular syphilis combined with neurosyphilis in patients who present with uveitis clinically and are diagnosed initially by an ophthalmologist.
Methods: This study is a retrospective, clinical investigation of seven male patients with ocular syphilis from a single tertiary center between 2009 and 2012.
Results: The average age of the patients at onset was 44.4 years (range, 33-71 years). Posterior segment involvement was found in all patients. Two patients had papillitis. In serologic testing, all patients had positive responses to Venereal Disease Research Laboratory (VDRL), fluorescent treponemal antibody-absorption test (FTA-ABS) and Treponema pallidum hemagglutination (TPHA). In fluorescein angiography (FAG), retinal vascular and disc leakage was the most common finding. Cerebrospinal fluid (CSF) analysis was performed for six patients and demonstrated positive CSF FTA-ABS and CSF TPHA tests in all patients. CSF VDRL was reactive in 2 patients (33.3%).
Conclusions: All patients with ocular syphilis were diagnosed with neurosyphilis based on the analysis of CSF with FTA-ABS and TPHA. Ophthalmologists play an important role in the early diagnosis and treatment of syphilis.
J Korean Ophthalmol Soc 2014;55(4):602-607
Ű¿öµå
CSF analysis, Neurosyphilis, Ocular syphilis
KMID :
0360220140550040602
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