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Two Cases of Superior Limbic Keratoconjunctivitis Treated with Bevacizumab and Triamcinolone Injection

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±è¿ø¼ö(Kim Won-Soo) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ ¾È°úÇб³½Ç
À§¼º¿í(Wee Sung-Wook) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ ¾È°úÇб³½Ç
±èÀçÂù(Kim Jae-Chan) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ ¾È°úÇб³½Ç

Abstract

¸ñ Àû: ±âÁ¸ÀÇ Ä¡·á¿¡ ºÒÀÀÇÏ´Â »óÀ±ºÎ °¢°á¸·¿° ȯÀÚ¿¡¼­ º£¹Ù½ÃÁÖ¸¿°ú Æ®¸®¾Ï½Ã³î·Ð È¥ÇÕÁ¦ Áֻ縦 ÀÌ¿ëÇÏ¿© Ä¡·áÇÑ 2¿¹¸¦ º¸°íÇϰíÀÚ ÇÑ´Ù.

Áõ·Ê¿ä¾à: 69¼¼ ¿©ÀÚ È¯ÀÚ°¡ 3ÀÏ ÀüºÎÅÍ ½ÃÀÛµÈ Á¾ÈÀÇ ÅëÁõÀ¸·Î ³»¿øÇÏ¿© »óÀ±ºÎ °¢°á¸·¿° Áø´Ü ¹Þ°í 3°³¿ù°£ ½ºÅ×·ÎÀ̵å Á¡¾ÈÁ¦, Àΰø´«¹°, °æ±¸ ½ºÅ×·ÎÀ̵带 ´Ü°èÀûÀ¸·Î »ç¿ëÇÏ¿´À¸³ª Ä¡·áµÇÁö ¾Ê¾Æ ±âÁ¸ Ä¡·á¿¡ ºÒÀÀÇÑ´Ù´Â ÆÇ´Ü ÇÏ¿¡ º£¹Ù½ÃÁÖ¸¿ 0.15 cc, Æ®¸®¾Ï ½Ã³î·Ð 0.05 ccÀ» È¥ÇÕÇÑ ÈÄ Å×³í³¶ ÇÏ¿¡ ÁÖ»çÇÏ¿´´Ù. ÁÖ»ç ÈÄ 1ÁÖÀÏ µÚ °æ°ú °üÂû¿¡¼­ Áõ»ó ¹× ÀÌÇÐÀû °Ë»ç ¼Ò°ß ¸ðµÎ¿¡¼­ È£ÀüÀ» º¸¿´°í ÀÌÈÄ 6°³¿ù°£ Àç¹ßÀÌ ¾ø¾ú´Ù. 55¼¼ ¿©ÀÚ È¯ÀÚ°¡ 3°³¿ù Àü ÁÂ¾È »óÀ±ºÎ °¢°á¸·¿° Áø´ÜÇÏ Àΰø´«¹°, ½ºÅ×·ÎÀ̵å Á¡¾ÈÁ¦, ´«¹°Á¡ Æó¼â, º¸Å彺 Ä¡·á¸¦ ´Ü°èÀûÀ¸·Î ½ÃÇàÇÏ¿´À¸³ª È£Àü ¾ø¾î Àü¿øµÇ¾ú´Ù. º£¹Ù½ÃÁÖ¸¿ 0.15 cc, Æ®¸®¾Ï½Ã³î·Ð 0.05 cc¸¦ È¥ÇÕÇÏ¿© Å×³í³¶ÇÏ¿¡ ÁÖ»çÇÑ ÈÄ 2ÁÖÀÏ µÚ Áõ»ó°ú ÀÌÇÐÀû °Ë»ç¿¡¼­ È£ÀüÀ» º¸¿´°í 4°³¿ù°£ Àç¹ßÀÌ ¾ø¾ú´Ù.

°á ·Ð: ±âÁ¸ÀÇ Ä¡·á¿¡ ºÒÀÀÇÏ´Â »óÀ±ºÎ °¢°á¸·¿°¿¡¼­ º£¹Ù½ÃÁÖ¸¿°ú Æ®¸®¾Ï½Ã³î·Ð È¥ÇÕÁ¦¸¦ Å×³í³¶ÇÏ¿¡ ÁÖ»çÇÏ¿© Ç÷°ü ½Å»ý°ú ¿°ÁõÀ» ÇÔ²² ¾ïÁ¦Çϸç ÁÁÀº Ä¡·á È¿°ú¸¦ º¸ÀΠù Áõ·ÊµéÀ̹ǷΠÀÇ¹Ì ÀÖ´Â °ÍÀ¸·Î »ý°¢µÈ´Ù.
Purpose: To report two cases of intractable superior limbic keratoconjunctivitis (SLK) treated with bevacizumab and triamcinolone
injection.

Case summary: A 69-year-old female visited our clinic with pain in the left eye for 3 days and was diagnosed with SLK in her left eye. After 3 months of using steroid eye drops, artificial tears, and oral steroid intermittently, there was no improvement in symptoms and signs, thus this case was considered intractable with the conventional therapy. A mixture of bevacizumab (0.15 cc) and triamcinolone (0.05 cc) was injected into the sub-tenon¡¯s capsule of the left eye. After 1 week, all
symptoms and signs disappeared, and there was no recurrence for 6 months. A 55-year-old female was transferred to our clinic due to SLK that did not respond to artificial tears, steroid eye drops, punctal occlusion, and botox injection for 3 months. A mixture of bevacizumab (0.15 cc) and triamcinolone (0.05 cc) was injected into the sub-tenon¡¯s capsule of the left eye. After 2 weeks, all symptoms and signs were improved, and there was no recurrence for 4 months.

Conclusions: The presented 2 SLK cases are meaningful, because neovascularization disappeared and controlled inflammation was obtained following sub-tenon injection with both bevacizumab and triamcinolone.

Ű¿öµå

Bevacizumab, Superior limbic keratoconjunctivitis, Triamcinolone
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