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Nasolacrimal Duct Obstruction after Radioactive Iodine Therapy for Thyroid Cancer
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Ȳ¹®¿ø(Hwang Moon-Won) - ÀÎÁ¦´ëÇб³ Àǰú´ëÇÐ ºÎ»ê¹éº´¿ø ¾È°úÇб³½Ç
ÀÌÀÀ(Lee Eung) - ÀÎÁ¦´ëÇб³ Àǰú´ëÇÐ ºÎ»ê¹éº´¿ø ¾È°úÇб³½Ç
¾çÀç¿í(Yang Jae-Wook) - ÀÎÁ¦´ëÇб³ Àǰú´ëÇÐ ºÎ»ê¹éº´¿ø ¾È°úÇб³½Ç
Abstract
¸ñÀû: °©»ó¼±¾Ï¿¡¼ ¹æ»ç¼º ¿ä¿Àµå Ä¡·á ÈÄ ¹ß»ýÇÑ ÄÚ´«¹°±æ Æó¼âÀÇ ÀÓ»ó¾ç»ó¿¡ ´ëÇØ ¾Ë¾Æº¸°íÀÚ ÇÏ¿´´Ù.
´ë»ó°ú ¹æ¹ý: 2009³â 1¿ùºÎÅÍ 2011³â 12¿ù±îÁö °©»ó¼±¾Ï ¼ö¼ú ÈÄ ¹æ»ç¼º ¿ä¿Àµå Ä¡·á¸¦ ¹ÞÀº ȯÀÚ ÃÑ 622¸í Áß ´«¹°È긲 Áõ»óÀ¸·Î ¼ºÇü ¾È°ú¿¡¼ °ü·ù°Ë»ç, ´õµëÀÚ °Ë»ç ¹× ´«¹°ÁÖ¸Ó´Ï Á¶¿µ¼úÀ» ÅëÇØ ÄÚ´«¹°±æ Æó¼â¸¦ Áø´Ü ¹ÞÀº 14¸í(18¾È)À» ´ë»óÀ¸·Î ÇÏ¿´´Ù. ´ë»óȯÀÚÀÇ ¹æ»ç¼º ¿ä¿Àµå Ä¡·á·®°ú Ƚ¼ö, ÄÚ´«¹°±æ Æó¼âÀÇ ÀÓ»ó¾ç»ó, Ä¡·á¹ýÀ» Àǹ«±â·ÏÀ» ÈÄÇâÀûÀ¸·Î ºÐ¼®ÇÏ¿© È®ÀÎÇÏ¿´´Ù.
°á°ú: ÄÚ´«¹°±æ Æó¼â°¡ Áø´ÜµÈ ȯÀÚ 14¸íÀº ÄÚ´«¹°±æ Æó¼â°¡ ¹ß»ýÇÏÁö ¾ÊÀº ȯÀÚ±º¿¡ ºñÇØ Æò±Õ Ä¡·á ¿ë·®(215.7 ¡¾ 23.1 mCi, p=0.01) °ú Ä¡·áȽ¼ö(1.36 ¡¾ 0.50ȸ, p£¼0.001)°¡ À¯ÀÇÇÏ°Ô ³ô¾Ò´Ù. ´«¹°È긲 Áõ»ó ¹ß»ý±îÁö Æò±Õ 10.2°³¿ù, Áø´Ü±îÁö Æò±Õ 18.4°³¿ùÀÌ °É·È´Ù. 14¸í(18¾È) Áß °øÅë´«¹°¼Ò°üÆó¼â´Â 3¸í(3¾È), ÄÚ´«¹°°üÆó¼â´Â 11¸í(15¾È)À̾ú´Ù. 10¸í(13¾È)Àº ´«¹°±æÀÇ ¿ÏÀüÆó¼â°¡ È®ÀÎµÇ¾î ³»½Ã°æÇÏ ´«¹°ÁÖ¸Ó´Ï Äھȿ¬°á¼úÀ» ½ÃÇà ¹Þ¾ÒÀ¸¸ç, 4¸í(5¾È)Àº ºÎºÐÆó¼â¸¦ º¸¿© ³»½Ã°æÇÏ ½Ç¸®ÄÜ °üÀ» »ðÀÔÇÏ¿´´Ù.
°á·Ð: °©»ó¼±¾Ï¿¡¼ ¹æ»ç¼º ¿ä¿Àµå Ä¡·á ÈÄ ÄÚ´«¹°±æ Æó¼â°¡ µå¹°°Ô ¹ß»ýÇÒ ¼ö ÀÖ´Ù. ¹æ»ç¼º ¿ä¿Àµå Ä¡·á ÈÄ ´«¹°È긲 Áõ»óÀ» È£¼ÒÇϴ ȯÀÚ°¡ ÀÖÀ» °æ¿ì ÇÕº´ÁõÀ¸·Î ÄÚ´«¹°±æ Æó¼â°¡ ¹ß»ýÇÒ ¼ö ÀÖÀ½À» ÀÎÁöÇϰí, Ãʱ⿡ ¼ºÇü¾È°ú¿¡ ÀÇ·ÚÇÏ¿© Àü¹®ÀûÀÎ Æò°¡ ¹× Ä¡·á°¡ ½ÃÇàµÇ¾î¾ß ÇÑ´Ù.
Purpose: To investigate the clinical manifestation of nasolacrimal duct obstruction after radioactive iodine therapy for thyroid cancer.
Methods: The authors examined 622 patients who were treated with radioactive iodine therapy after the operation for thyroid cancer from January 2009 to December 2011. Fourteen patients (18 eyes) were diagnosed nasolacrimal duct obstruction based on the lacrimal irrigation test, lacrimal probing test and dacryocystography in our oculoplastic clinic. We analyzed the dose of radioactive iodine therapy, number of treatments, clinical manifestation and treatment type by retrospectively reviewing the patients¡¯ medical records.
Results: The mean radioactive iodine dose (215.7 ¡¾ 23.1 mCi, p = 0.01) and the mean number of treatments (1.36 ¡¾ 0.50, p < 0.001) were significantly greater in 14 patients who had nasolacrimal duct obstruction than in patients who did not. The average onset of tearing symptoms occurred 10.2 months after radioactive iodine therapy. The mean time between correct diagnosis and therapy was 18.4 months. Three patients (3 eyes) had occlusion at the common cannaliculus and 11 patients (15 eyes) had occlusion at the nasolacrimal duct. Ten patients (13 eyes) underwent endonasal dacryocystorhinostomy for complete obstruction and 4 patients (5 eyes) underwent silicone tube intubation for partial obstruction.
Conclusions: Nasolacrimal duct obstruction is a rare complication associated with radioactive iodine therapy for thyroid cancer, thus, clinicians should be aware of this complication and refer patients with symptoms of epiphora to the oculoplastic department for specialized evaluation and treatment.
Ű¿öµå
Nasolacrimal duct obstruction, Radioactive iodine, Thyroid cancer
KMID :
0360220140550010001
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