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야간근육경련의 페니토인 치료효과: 예비연구
Efficacy of Phenytoin for Nocturnal Muscle Cramps: A Preliminary Study

대한신경과학회지 2014년 32권 4호 p.254 ~ p.258

김경민(Kim Kyung-Min) - 연세대학교 의과대학 신경과학교실
이동현(Lee Dong-Hyun) - 연세대학교 의과대학 신경과학교실
이윤주(Lee Yoon-Ju) - 연세대학교 의과대학 신경과학교실
이한(Yi Han) - 연세대학교 의과대학 신경과학교실
조양제(Cho Yang-Je) - 연세대학교 의과대학 신경과학교실
이병인(Lee Byung-In) - 연세대학교 의과대학 신경과학교실
허경(Heo Kyoung) - 연세대학교 의과대학 신경과학교실

Abstract

Background: Nocturnal muscle cramps are sudden, involuntary, painful muscle contractions that occur in the night and are accompanied by hardening of the muscles. Many symptomatic treatments have been introduced for nocturnal muscle cramps, such as quinine, magnesium, and phenytoin. However, the efficacy and safety of these drugs have not been adequately evaluated. To demonstrate the efficacy and safety of phenytoin treatment for nocturnal muscle cramps, we conducted a retrospective study of 16 patients with nocturnal muscle cramps.

Methods: We reviewed 16 patients (6 men, 10 women) who suffered frequent nocturnal muscle cramps and were treated with phenytoin. The patients’ clinical information (age, sex, disease duration, and locations of cramps), treatment dosage, and frequency of cramps were obtained by reviewing their medical records.

Results: The patients were aged 63.1±14.7 years (mean±SD; age range, 30-80 years; median age, 68 years). Twelve and four patients received phenytoin doses of 100 and 200 mg/day, respectively. The median duration of medication was 51 days (range, 14-378 days). Phenytoin treatment was effective in all patients; 13 patients (81.3%) experienced a total remission of their symptoms, and a significant reduction (66.7-85.7%) in the frequency of cramps was found in the remaining 3 patients. No adverse effects were reported by any of the patients.

Conclusions: While this retrospective study was conducted with only a small number of patients, the clinical results suggest that phenytoin is a safe and helpful therapy for the treatment of nocturnal muscle cramps.

키워드

Phenytoin, Muscle cramps, Drug therapy

KMID : 0359720140320040254

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주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

연구비지원(Fund Source)

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참여저자수(Authors)

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DOI

KCD코드

ICD 03

건강보험코드

야간근육경련의 페니토인 치료효과: 예비연구 Efficacy of Phenytoin for Nocturnal Muscle Cramps: A Preliminary Study

Abstract

키워드

야간근육경련의 페니토인 치료효과: 예비연구
Efficacy of Phenytoin for Nocturnal Muscle Cramps: A Preliminary Study