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Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate

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ÀÌÁÖ¿¬(Lee Ju-Youn) - Ãæ³²´ëÇб³ Àǰú´ëÇÐ Ãæ³²´ëÇб³º´¿ø ½Å°æ°ú
¿ÀÀÀ¼®(Oh Eung-Seok) - Ãæ³²´ëÇб³ Àǰú´ëÇÐ Ãæ³²´ëÇб³º´¿ø ½Å°æ°ú
Á¤¼ºÇØ(Jeong Seong-Hae) - Ãæ³²´ëÇб³ Àǰú´ëÇÐ Ãæ³²´ëÇб³º´¿ø ½Å°æ°ú
¼ÕÀºÈñ(Sohn Eun-Hee) - Ãæ³²´ëÇб³ Àǰú´ëÇÐ Ãæ³²´ëÇб³º´¿ø ½Å°æ°ú
Àֿ̾µ(Lee Ae-Young) - Ãæ³²´ëÇб³ Àǰú´ëÇÐ Ãæ³²´ëÇб³º´¿ø ½Å°æ°ú

Abstract

Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy associated with oral MTX.

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Leukoencephalopathy, Methotrexate, Cerebellum
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DOI
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ICD 03
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