A meningomyelocele with normal intracranial signs on ultrasound and false-negative amniotic fluid alpha-fetoprotein and acetylcholinesterase
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(Yoon Chong-Hyeok) - Eulji University School of Medicine Department of Obstetrics and Gynecology
°»ó±Ô(Kang Sang-Kyu) - Eulji University School of Medicine Department of Obstetrics and Gynecology
ÁøÂùÈñ(Jin Chan-Hee) - Eulji University School of Medicine Department of Obstetrics and Gynecology
¹Ú¹®¼±(Park Moon-Sun) - Eulji University College of Medicine Eulji University Hospital Department of Neurosurgery
(Rho Jeong-Hoon) - Eulji University School of Medicine Department of Obstetrics and Gynecology
Abstract
Neural tube defects are the major targets of prenatal diagnoses, along with Down syndrome. Prenatal diagnosis of spina bifida is possible at second trimester of gestation through ¥á-fetoprotein and acetylcholinesterase biochemistry assays and ultrasound. In particular, the discovery of characteristic intracranial signs on ultrasound leads to a very high diagnosis rate. However, it is rare for spina bifida to present without intracranial signs while also showing normal values of maternal serum ¥á-fetoprotein, amniotic fluid ¥á-fetoprotein, and acetylcholinesterase. In our hospital, a fetus with spina bifida was delivered at 37+5 weeks¡¯ gestation by cesarean section, and was continually followed up over 2 years to date.
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Intracranial sign, Meningocele, Meningocele repair, Maternal serum alpha-fetoproteins, Spinal dysraphism
KMID :
0358420140570030223
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