Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery
´ëÇÑ»êºÎÀΰúÇÐȸÁö 2014³â 57±Ç 2È£ p.109 ~ p.114
³ëÀºÁö(Noh Eun-Ji) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÀ±ÇÏ(Kim Yoon-Ha) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Á¶¹®°æ(Cho Moon-Kyoung) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÁ¾À±(Kim Jong-Woon) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÁø¿í(Kim Jin-Wook) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
º¯¿µÀÚ(Byun Yeung-Ja) - Àü³²´ëÇб³ ÀÇ°úÇבּ¸¼Ò
¼Ûź¹(Song Tae-Bok) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Abstract
Objective: The purpose of our study was to investigate the effect of the mode of delivery on the oxidant and antioxidant system in umbilical cord blood.
Methods: We performed gas analysis of umbilical venous blood and umbilical arterial blood immediately after delivery in 38 women; eighteen women had a vaginal delivery while 20 women delivered via cesarean section at over 37 weeks gestation. We examined lipid peroxide concentration by thiobarbituric acid reaction, protein carbonyl content by 2,4-dinitrophenylhydrazine reaction, and total antioxidant capacity by oxygen radical absorbance capacity assay.
Results: Lipid peroxide levels in umbilical venous blood were significantly higher in patients delivering by planned cesarean section (1.81 ¡¾ 0.06 nmol/mg protein) than those with vaginal delivery (1.24 ¡¾ 0.05 nmol/mg protein) (P < 0.05). Antioxidant capacity in umbilical venous blood was significantly higher in patients delivering by planned cesarean section (119.70 ¡¾ 0.13 ¥ìM/¥ìL) than those with a vaginal delivery (118.70 ¡¾ 0.29 ¥ìM/¥ìL) (P < 0.05). There was no significant difference in the carbonyl content of umbilical venous blood or in the lipid peroxide, carbonyl content, and total antioxidant capacity of umbilical arterial blood.
Conclusion: Lipid peroxidation levels and antioxidant capacity in umbilical venous blood were higher in patients delivering by planned cesarean section than those with a vaginal delivery. Therefore, we propose that both the mother and neonate are exposed to higher oxidative stress during cesarean section delivery.
Å°¿öµå
Cesarean delivery, Oxidative stress marker, Vaginal delivery
KMID :
0358420140570020109
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)