Prognostic value of pretreatment hemoglobin level in patients with early cervical cancer
´ëÇÑ»êºÎÀΰúÇÐȸÁö 2014³â 57±Ç 1È£ p.28 ~ p.36
½Å³ª¸®(Shin Na-Ri) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
ÀÌÀ¯¿µ(Lee Yoo-Young) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
±è½ÂÇö(Kim Seung-Hyun) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
ÃÖöÈÆ(Choi Chel-Hun) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
±èÅÂÁß(Kim Tae-Joong) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
ÀÌÁ¤¿ø(Lee Jeong-Won) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
¹è´ö¼ö(Bae Duk-Soo) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
±èº´±â(Kim Byoung-Gie) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Obstetrics and Gynecology
Abstract
Objective: The purpose of this study is to investigate the prognostic role of pretreatment anemia in patients with early cervical cancer who underwent radical hysterectomy.
Methods: In this study, we retrospectively enrolled patients with early cervical cancer (International Federation of Obstetrics and Gynecology stage IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea, from 1996 to 2007.
Results: We retrospectively enrolled 805 patients. Median pretreatment hemoglobin (Hb) level was 12.8 g/dL (4.0-16.9) in all patients. Ninety-ninth out of 805 patients had pretreatment anemia (12.3%). Pretreatment anemia was significantly associated with large tumor size, advanced clinical stage, and parametrial invasion. In multivariate analysis, higher pretreatment Hb entailed better prognostic significance in disease free survival (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.078-0.99) but not in overall survival (HR, 0.94; 95% CI, 0.80-1.10).
Conclusion: In conclusion, we found that the negative association between pretreatment Hb level and tumor size and the impact of anemia before treatment on disease free survival adjusted for other factors including clinical stage and pathological findings in early stage cervical cancer.
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Anemia, Hemoglobins, Prognosis, Survival, Uterine cervical neoplasms
KMID :
0358420140570010028
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